Pathomorphological and biosynthetic changes in gastric epithelium during chronic duodenal ulcer

被引：0
作者：
Lapii, GA [1 ]
Abramova, EE [1 ]
Nepomnyashchikh, DL [1 ]
机构：
[1] Russian Acad Med Sci, Siberian Div, Inst Reg Pathol & Pathomorphol, Lab Clin Morphol,Lab Ultrastruct Bases Pathol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 06期
关键词：
peptic ulcer; gastric epithelium; electron microscopy; autoradiography;
D O I：
10.1023/A:1012375207675
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied structural changes and biosynthetic processes in the gastric epithelium in patients with chronic duodenal ulcer. The severity of alterative ultrastructural changes in surface epithelial and glandular cells progressively increased from proximal to distal portion of the stomach. Biosynthesis of nucleic acids within the epithelium depended on the morphofunctional state of epitheliocytes. DNA biosynthesis in the fundus was less intensive. The intensity of RNA synthesis did not differ between various gastric regions. Our results suggest that structural and metabolic dimorphism of the fundic and pyloric epithelium underlies pathological changes in the mucosa during ulcer disease.
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页码：595 / 600
页数：6
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