Amoxicillin-Clavulanic Acid Hepatotoxicity in Children

被引：8

作者：

Hita, Esther Ocete ^{[1
]}

Garcia, Jose Antonio Martin ^{[1
]}

Gonzalez, Jose Carlos Flores ^{[3
]}

Molina, Ana Abril ^{[1
]}

Cordero, Ma Jose Aguilar ^{[2
]}

Escobar, Javier Salmeron ^{[1
]}

Ruiz-Extremera, Angela ^{[2
]}

机构：

[1] Hosp Univ Virgen Nieves, Granada, Spain

[2] Hosp Univ San Cecilio, Granada, Spain

[3] Hosp Univ Virgen del Mar, Cadiz, Spain

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2012年 / 55卷 / 06期

关键词：

adverse drug reaction; amoxycillin-clavulanic acid; hepatotoxicity; pediatric; ADVERSE DRUG-REACTIONS; INDUCED LIVER-INJURY; ANTIBIOTICS; COMBINATION; FEATURES;

D O I：

10.1097/MPG.0b013e318263ebfa

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: The objectives of the present study were to determine the importance of amoxicillin-clavulanic acid (AC) hepatotoxicity in the paediatric population and to characterise the episodes identified and potential host-specific factors. This was addressed via a prospective observational study in which 8 Spanish hospitals participated. Methods: A total of 11 cases were examined. For each patient included in the study, a structured and codified data-collection protocol was complied with, taking note of patient demographics, characteristics of the treatment assumed to provoke the reaction, concomitant medication, course and outcome of the episode, and laboratory variables during the reaction. The latter were determined every 6 months from the outset to the eventual resolution of the case. Results: A total of 11 cases of AC hepatotoxicity were detected, affecting 9 boys and 2 girls, ages 1 to 11 years. Causality criteria were assessed using the Council for International Organizations of Medical Sciences scale. Conclusions: We conclude that the introduction of hepatotoxicity record systems in paediatric care, together with the continuing study and development of existing systems, would contribute to improving our epidemiological knowledge about the harmful effects of drugs on the liver.

引用

页码：663 / 667

页数：5