Structural Vaccinology for Viral Vaccine Design

被引：46
作者：
Anasir, Mohd Ishtiaq [1 ]
Poh, Chit Laa [1 ]
机构：
[1] Sunway Univ, Ctr Virus & Vaccine Res, Bandar Sunway, Malaysia
来源：
FRONTIERS IN MICROBIOLOGY | 2019年 / 10卷
关键词：
structural vaccinology; vaccine design; protein structure; epitope; virus; HEPATITIS-C-VIRUS; ENVELOPE DOMAIN-III; HUMAN MONOCLONAL-ANTIBODIES; DENGUE VIRUS; NEUTRALIZING ANTIBODIES; CRYSTAL-STRUCTURES; PARTICLES PROVIDE; RATIONAL DESIGN; FUSION PROTEIN; ENTEROVIRUS; 71;
D O I：
10.3389/fmicb.2019.00738
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viruses such as human immunodeficiency virus (HIV), hepatitis C virus, enterovirus A71, and dengue virus. Recent studies demonstrated that applications of this structural information can solve some of the vaccine conundrums. This review focuses on recent advances in structure-based vaccine design, or structural vaccinology, for novel and innovative viral vaccine design.
引用
收藏
页数：11
相关论文
共 93 条
  • [81] Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV
    Steff, Ann-Muriel
    Monroe, James
    Friedrich, Kristian
    Chandramouli, Sumana
    Thi Lien-Anh Nguyen
    Tian, Sai
    Vandepaer, Sarah
    Toussaint, Jean-Francois
    Carfi, Andrea
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [82] Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33
    Tarr, AW
    Owsianka, AM
    Timms, JM
    McClure, CP
    Brown, RJP
    Hickling, TP
    Pietschmann, T
    Bartenschlager, R
    Patel, AH
    Ball, JK
    [J]. HEPATOLOGY, 2006, 43 (03) : 592 - 601
  • [83] Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency
    Tharakaraman, Kannan
    Robinson, Luke N.
    Hatas, Andrew
    Chen, Yi-Ling
    Liu Siyue
    Raguram, S.
    Sasisekharan, V.
    Wogan, Gerald N.
    Sasisekharan, Ram
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (17) : E1555 - E1564
  • [84] A recombinant Fab neutralizes dengue virus in vitro
    Thullier, P
    Lafaye, P
    Mégret, F
    Deubel, V
    Jouan, A
    Mazié, JC
    [J]. JOURNAL OF BIOTECHNOLOGY, 1999, 69 (2-3) : 183 - 190
  • [85] Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes:: insight into the neutralization mechanism
    Thullier, P
    Demangel, C
    Bedouelle, H
    Mégret, F
    Jouan, A
    Deubel, V
    Mazié, JC
    Lafaye, P
    [J]. JOURNAL OF GENERAL VIROLOGY, 2001, 82 : 1885 - 1892
  • [86] Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory
    Van Regenmortel, Marc H. V.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (09)
  • [87] Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions
    Wang, Guangchuan
    Cao, Rui-Yuan
    Chen, Rong
    Mo, Lijuan
    Han, Jian-Feng
    Wang, Xiaoyu
    Xu, Xurong
    Jiang, Tao
    Deng, Yong-Qiang
    Lyu, Ke
    Zhu, Shun-Ya
    Qin, E-De
    Tang, Ruikang
    Qin, Cheng-Feng
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) : 7619 - 7624
  • [88] Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop
    Wang, Haoqing
    Cohen, Alexander A.
    Galimidi, Rachel P.
    Gristick, Harry B.
    Jensen, Grant J.
    Bjorkman, Pamela J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (46) : E7151 - E7158
  • [89] A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine
    Wu, Nicholas C.
    Zost, Seth J.
    Thompson, Andrew J.
    Oyen, David
    Nycholat, Corwin M.
    McBride, Ryan
    Paulson, James C.
    Hensley, Scott E.
    Wilson, Ian A.
    [J]. PLOS PATHOGENS, 2017, 13 (10)
  • [90] Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
    Wu, Xueling
    Yang, Zhi-Yong
    Li, Yuxing
    Hogerkorp, Carl-Magnus
    Schief, William R.
    Seaman, Michael S.
    Zhou, Tongqing
    Schmidt, Stephen D.
    Wu, Lan
    Xu, Ling
    Longo, Nancy S.
    McKee, Krisha
    O'Dell, Sijy
    Louder, Mark K.
    Wycuff, Diane L.
    Feng, Yu
    Nason, Martha
    Doria-Rose, Nicole
    Connors, Mark
    Kwong, Peter D.
    Roederer, Mario
    Wyatt, Richard T.
    Nabel, Gary J.
    Mascola, John R.
    [J]. SCIENCE, 2010, 329 (5993) : 856 - 861
12345678910