Structural Vaccinology for Viral Vaccine Design

被引：49

作者：

Anasir, Mohd Ishtiaq ^{[1
]}

Poh, Chit Laa ^{[1
]}

机构：

[1] Sunway Univ, Ctr Virus & Vaccine Res, Bandar Sunway, Malaysia

来源：

FRONTIERS IN MICROBIOLOGY | 2019年 / 10卷

关键词：

structural vaccinology; vaccine design; protein structure; epitope; virus; HEPATITIS-C-VIRUS; ENVELOPE DOMAIN-III; HUMAN MONOCLONAL-ANTIBODIES; DENGUE VIRUS; NEUTRALIZING ANTIBODIES; CRYSTAL-STRUCTURES; PARTICLES PROVIDE; RATIONAL DESIGN; FUSION PROTEIN; ENTEROVIRUS; 71;

D O I：

10.3389/fmicb.2019.00738

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viruses such as human immunodeficiency virus (HIV), hepatitis C virus, enterovirus A71, and dengue virus. Recent studies demonstrated that applications of this structural information can solve some of the vaccine conundrums. This review focuses on recent advances in structure-based vaccine design, or structural vaccinology, for novel and innovative viral vaccine design.

引用

页数：11

共 93 条

[81] Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV [J].

Steff, Ann-Muriel ;

Monroe, James ;

Friedrich, Kristian ;

Chandramouli, Sumana ;

Thi Lien-Anh Nguyen ;

Tian, Sai ;

Vandepaer, Sarah ;

Toussaint, Jean-Francois ;

Carfi, Andrea .

NATURE COMMUNICATIONS, 2017, 8

[82] Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33 [J].

Tarr, AW ;

Owsianka, AM ;

Timms, JM ;

McClure, CP ;

Brown, RJP ;

Hickling, TP ;

Pietschmann, T ;

Bartenschlager, R ;

Patel, AH ;

Ball, JK .

HEPATOLOGY, 2006, 43 (03) :592-601

[83] Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency [J].

Tharakaraman, Kannan ;

Robinson, Luke N. ;

Hatas, Andrew ;

Chen, Yi-Ling ;

Liu Siyue ;

Raguram, S. ;

Sasisekharan, V. ;

Wogan, Gerald N. ;

Sasisekharan, Ram .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (17) :E1555-E1564

[84] A recombinant Fab neutralizes dengue virus in vitro [J].

Thullier, P ;

Lafaye, P ;

Mégret, F ;

Deubel, V ;

Jouan, A ;

Mazié, JC .

JOURNAL OF BIOTECHNOLOGY, 1999, 69 (2-3) :183-190

[85] Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes:: insight into the neutralization mechanism [J].

Thullier, P ;

Demangel, C ;

Bedouelle, H ;

Mégret, F ;

Jouan, A ;

Deubel, V ;

Mazié, JC ;

Lafaye, P .

JOURNAL OF GENERAL VIROLOGY, 2001, 82 :1885-1892

[86] Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory [J].

Van Regenmortel, Marc H. V. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (09)

[87] Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions [J].

Wang, Guangchuan ;

Cao, Rui-Yuan ;

Chen, Rong ;

Mo, Lijuan ;

Han, Jian-Feng ;

Wang, Xiaoyu ;

Xu, Xurong ;

Jiang, Tao ;

Deng, Yong-Qiang ;

Lyu, Ke ;

Zhu, Shun-Ya ;

Qin, E-De ;

Tang, Ruikang ;

Qin, Cheng-Feng .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) :7619-7624

[88] Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop [J].

Wang, Haoqing ;

Cohen, Alexander A. ;

Galimidi, Rachel P. ;

Gristick, Harry B. ;

Jensen, Grant J. ;

Bjorkman, Pamela J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (46) :E7151-E7158

[89] A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine [J].

Wu, Nicholas C. ;

Zost, Seth J. ;

Thompson, Andrew J. ;

Oyen, David ;

Nycholat, Corwin M. ;

McBride, Ryan ;

Paulson, James C. ;

Hensley, Scott E. ;

Wilson, Ian A. .

PLOS PATHOGENS, 2017, 13 (10)

[90] Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1 [J].

Wu, Xueling ;

Yang, Zhi-Yong ;

Li, Yuxing ;

Hogerkorp, Carl-Magnus ;

Schief, William R. ;

Seaman, Michael S. ;

Zhou, Tongqing ;

Schmidt, Stephen D. ;

Wu, Lan ;

Xu, Ling ;

Longo, Nancy S. ;

McKee, Krisha ;

O'Dell, Sijy ;

Louder, Mark K. ;

Wycuff, Diane L. ;

Feng, Yu ;

Nason, Martha ;

Doria-Rose, Nicole ;

Connors, Mark ;

Kwong, Peter D. ;

Roederer, Mario ;

Wyatt, Richard T. ;

Nabel, Gary J. ;

Mascola, John R. .

SCIENCE, 2010, 329 (5993) :856-861

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