Amphiphilic α-helix mimetics based on a benzoylurea scaffold

被引：37
|
作者：
Thompson, Sam [1 ]
Hamilton, Andrew D. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 30期
关键词：
PROTEIN; INHIBITORS; PEPTIDES; RECEPTOR; BINDING;
D O I：
10.1039/c2ob25273b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The design and synthesis of amphiphilic benzoylurea alpha-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an alpha-helix.
引用
收藏
页码：5780 / 5782
页数：3
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