Cell-surface-bound circulating DNA as a prognostic factor in lung cancer

被引：19

作者：

Tamkovich, Svetlana N. ^{[1
,2
]}

Litviakov, Nikolai V. ^{[3
]}

Bryzgunova, Olga E. ^{[1
]}

Dobrodeev, Aleksey Yu. ^{[3
]}

Rykova, Elena Yu. ^{[1
]}

Tuzikov, Sergey A. ^{[3
]}

Zav'ialov, Aleksandr A. ^{[3
]}

Vlassov, Valentin V. ^{[1
]}

Cherdyntseva, Nadezhda V. ^{[3
]}

Laktionov, Pavel P. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Div, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

[3] Russian Acad Med Sci, Canc Res Inst, Siberian Div, Tomsk, Russia

来源：

CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM V | 2008年 / 1137卷

基金：

俄罗斯基础研究基金会;

关键词：

circulating DNA; cell-surface-bound DNA; extracellular nucleic acids; lung cancer; blood;

D O I：

10.1196/annals.1448.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the mortality of lung cancer patients remains very high, development of prognostic methods essential for efficient therapy is an immediate task. This study was designed to assess the value of circulating DNA (cirDNA) in blood as a prognostic marker in patients with non-small cell lung cancer. The average concentration of cirDNA in plasma was shown to be similar in healthy donors and lung cancer patients. However, the concentration of cell-surface-bound circulating DNA (csb-cirDNA) in lung cancer patients is significantly lower than that found in healthy donors (P < 0.0001) and correlates with a poor prognosis of tumor disease. Quantification of the cell-surface-bound DNA in blood of untreated patients allows persons with a poor prognosis of tumor disease to be detected with 94% sensitivity and 50% specificity.

引用

页码：214 / 217

页数：4

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