Iodine-DMSO promoted C-H (SP3) functionalization approach to α-ketoamides

被引：41
作者：
Mupparapu, Nagaraju [1 ,2 ]
Vishwakarma, Ram A. [1 ,2 ]
Ahmed, Qazi Naveed [1 ,2 ]
机构：
[1] Indian Inst Integrat Med, Div Med Chem, Jammu, India
[2] Acad Sci & Innovat Res AcSIR, Cent Rd Res Inst, New Delhi 110025, India
来源：
TETRAHEDRON | 2015年 / 71卷 / 21期
关键词：
Oxidative coupling; alpha-Ketoamides; DMSO; C-H functionalization; Metal free; METAL-FREE; DOUBLE CARBONYLATION; OXIDATIVE SYNTHESIS; EFFICIENT SYNTHESIS; METHYL KETONES; ACCESS; AMINES; ACETOPHENONES; ACIDS; DERIVATIVES;
D O I：
10.1016/j.tet.2015.03.088
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile access to alpha-ketoamides employing an efficient I-2-DMSO promoted oxidative coupling reaction conditions between commercially available arylmethylketones and amines under metal free condition is presented. Mechanistic studies revealed C-1-oxygen atom of alpha-ketoamides is derived from DMSO. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3417 / 3421
页数：5
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