Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

被引：35

作者：

Liu, Yushuai ^{[1
]}

Geng, Yuanyuan ^{[2
,3
]}

Yue, Beilei ^{[2
,3
]}

Lo, Pui-Chi ^{[4
]}

Huang, Jing ^{[2
,3
]}

Jin, Honglin ^{[2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan, Peoples R China

[2] Huazhong Agr Univ, Coll Biomed & Hlth, Wuhan, Peoples R China

[3] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China

[4] City Univ Hong Kong, Dept Biomed Sci, Kowloon, Hong Kong, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

cancer immunotherapy; tumor microenvironment (TME); injectable hydrogels; immunogenic cell death; abscopal effect; controlled drug release; IMMUNE CHECKPOINT BLOCKADE; DRUG-DELIVERY SYSTEM; REGULATORY T-CELLS; CANCER-IMMUNOTHERAPY; VASCULAR NORMALIZATION; SUPPRESSOR-CELLS; CO-DELIVERY; MACROPHAGES; COMBINATION; GROWTH;

D O I：

10.3389/fimmu.2021.832942

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer immunotherapy can boost the immune response of patients to eliminate tumor cells and suppress tumor metastasis and recurrence. However, immunotherapy resistance and the occurrence of severe immune-related adverse effects are clinical challenges that remain to be addressed. The tumor microenvironment plays a crucial role in the therapeutic efficacy of cancer immunotherapy. Injectable hydrogels have emerged as powerful drug delivery platforms offering good biocompatibility and biodegradability, minimal invasion, convenient synthesis, versatility, high drug-loading capacity, controlled drug release, and low toxicity. In this review, we summarize the application of injectable hydrogels as a unique platform for targeting the immunosuppressive tumor microenvironment.

引用

页数：14

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