Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

被引：35
作者：
Liu, Yushuai [1 ]
Geng, Yuanyuan [2 ,3 ]
Yue, Beilei [2 ,3 ]
Lo, Pui-Chi [4 ]
Huang, Jing [2 ,3 ]
Jin, Honglin [2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan, Peoples R China
[2] Huazhong Agr Univ, Coll Biomed & Hlth, Wuhan, Peoples R China
[3] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China
[4] City Univ Hong Kong, Dept Biomed Sci, Kowloon, Hong Kong, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
cancer immunotherapy; tumor microenvironment (TME); injectable hydrogels; immunogenic cell death; abscopal effect; controlled drug release; IMMUNE CHECKPOINT BLOCKADE; DRUG-DELIVERY SYSTEM; REGULATORY T-CELLS; CANCER-IMMUNOTHERAPY; VASCULAR NORMALIZATION; SUPPRESSOR-CELLS; CO-DELIVERY; MACROPHAGES; COMBINATION; GROWTH;
D O I：
10.3389/fimmu.2021.832942
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cancer immunotherapy can boost the immune response of patients to eliminate tumor cells and suppress tumor metastasis and recurrence. However, immunotherapy resistance and the occurrence of severe immune-related adverse effects are clinical challenges that remain to be addressed. The tumor microenvironment plays a crucial role in the therapeutic efficacy of cancer immunotherapy. Injectable hydrogels have emerged as powerful drug delivery platforms offering good biocompatibility and biodegradability, minimal invasion, convenient synthesis, versatility, high drug-loading capacity, controlled drug release, and low toxicity. In this review, we summarize the application of injectable hydrogels as a unique platform for targeting the immunosuppressive tumor microenvironment.
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页数：14
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