Fluoride-induced apoptosis and expressions of caspase proteins in the kidney of carp (Cyprinus carpio)

被引：29

作者：

Chen, Jianjie ^{[1
]}

Cao, Jinling ^{[1
]}

Wang, Jundong ^{[1
]}

Jia, Ruhui ^{[1
]}

Xue, Wenjuan ^{[1
]}

Xie, Lingtian ^{[2
]}

机构：

[1] Shanxi Agr Univ, Coll Anim Sci & Vet Med, State Key Lab Ecol Anim Husb & Environm Vet Med, Taigu 030801, Shanxi, Peoples R China

[2] Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang 110016, Liaoning, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY | 2015年 / 30卷 / 07期

关键词：

fluoride; kidney; oxidative stress; apoptosis; expression of caspase proteins; Cyprinus carpio; FRESH-WATER TELEOST; OXIDATIVE STRESS; SODIUM-FLUORIDE; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; MALE RATS; TOXICITY; DAMAGE; ANTIOXIDANT; EXPOSURE;

D O I：

10.1002/tox.21956

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The study was conducted to investigate oxidative stress, apoptosis, and protein expressions of caspase-3, 8, and 9 in kidney of the carp juveniles exposed to 0, 40, 80, 120, and 160 mg L-1 of fluoride (in the form of NaF) for 90 days. The results showed that dose- and time-dependent decrease of SOD and GSH and dose- and time-dependent increase of MDA were observed in the carp juveniles, which suggested that fluoride induced oxidative damage accompanied with morphological changes and significant apoptosis in fish exposed to fluoride, especially in the higher doses. Fluoride exposure also significantly elevated the protein expressions of caspase-3, 8, and 9. In conclusion, these results indicate that chronic exposure to fluoride causes oxidative stress, damages the kidney structure, and results in renal apoptosis by caspase-dependent pathway. (c) 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 769-781, 2015.

引用

页码：769 / 781

页数：13

共 56 条

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