A case study of a child with chronic hemolytic anemia due to a Donath-Landsteiner positive, IgM anti-I autoantibody

被引：9

作者：

Karafin, Matthew S. ^{[2
]}

Shirey, R. Sue ^{[2
]}

Ness, Paul M. ^{[2
]}

King, Karen E. ^{[2
]}

Keefer, Jeffrey ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Johns Hopkins Med Inst, Dept Pediat, Div Pediat Hematol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ Hosp, Dept Pathol, Div Transfus Med, Baltimore, MD 21287 USA

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 05期

关键词：

anemias; blood bank; IVIG; hemolytic anemia; immunotherapy; PAROXYSMAL COLD HEMOGLOBINURIA; BIPHASIC HEMOLYSIN; AUTOIMMUNE HEMOLYSIS; ANTIBODIES;

D O I：

10.1002/pbc.24185

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In children, paroxysmal cold hemoglobinuria (PCH) is generally considered an acute self-limited autoimmune hemolytic anemia caused by an IgG biphasic auto-anti-P antibody identified by the DonathLandsteiner (D-L) test. We report a case of a 5-year-old female with a chronic hemolytic anemia. The etiology of the hemolysis appears to be an unusual D-L positive, IgM antibody with specificity for the I antigen. The clinical course is described and a discussion of PCH and the D-L antibody is presented. We also discuss intravenous immunoglobulin infusions as a therapy for children with this form of severe chronic autoimmune hemolytic anemia. Pediatr Blood Cancer 2012; 59: 953955. (C) 2012 Wiley Periodicals, Inc.

引用

页码：953 / 955

页数：3

共 3 条

[1] Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report
Prince, Sara D.
Winestone, Lena E.
Nance, Sandra J.
Friedman, David F.
TRANSFUSION, 2017, 57 (06) : 1401 - 1406
[2] A rare case report of autoimmune haemolytic anemia in a female child due to a Donath-Landsteiner antibody
Radonjic, Z.
Andric, B.
Serbic, O.
Micic, D.
Kuzmanovic, M.
Jovanovic-Srzentic, S.
Dinic, R.
TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2020, 27 (02) : 83 - 86
[3] Successful Treatment of Warm Autoimmune Hemolytic Anemia with a Positive Donath-Landsteiner Test Using Rituximab
Hiranuma, Naoko
Koba, Yusuke
Kawata, Takahito
Tamekane, Akira
Watanabe, Mitsumasa
INTERNAL MEDICINE, 2024, 63 (15) : 2173 - 2176

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