Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behcet's disease by up-front cord blood transplantation

被引：34

作者：

Nonami, Atsushi ^{[1
]}

Takenaka, Katsuto ^{[1
]}

Sumida, Chinatsu ^{[1
]}

Aizawa, Kumiko ^{[1
]}

Kamezaki, Kenjiro ^{[1
]}

Miyamoto, Toshihiro ^{[1
]}

Harada, Naoki ^{[1
]}

Nagafuji, Koji ^{[1
]}

Teshima, Takanori ^{[1
]}

Harada, Mine ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med, Dept Internal Med 1, Fukuoka 812, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 20期

关键词：

trisomy; 8; cord blood transplantation;

D O I：

10.2169/internalmedicine.46.0291

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Behcet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behcet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behcet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behcet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behcet's disease.

引用

页码：1753 / 1756

页数：4

共 19 条

[1] Adachi Y, 2003, Mod Rheumatol, V13, P90, DOI 10.3109/s101650300015
[2] Phase I/II trial of autologous stem cell transplantation in systemic sclerosis:: procedure related mortality and impact on skin disease
Binks, M
Passweg, JR
Furst, D
McSweeney, P
Sullivan, K
Besenthal, C
Finke, J
Peter, HH
van Laar, J
Breedveld, FC
Fibbe, VE
Farge, D
Gluckman, E
Locatelli, F
Martini, A
van den Hoogen, F
van de Putte, L
Schattenberg, AVN
Arnold, R
Bacon, PA
Emery, P
Espigado, I
Hertenstein, B
Hiepe, F
Kashyap, A
Kötter, I
Marmont, A
Martinez, A
Pascual, MJ
Gratwohl, A
Prentice, HG
Black, C
Tyndall, A
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (06) : 577 - 584
[3] GREENBERG PL, 1983, BLOOD, V61, P1035
[4] Feasibility of Allogeneic Hematopoietic Stem Cell Transplantation for Autoimmune Disease: Position Statement from a National Institute of Allergy and Infectious Diseases and National Cancer Institute-Sponsored International Workshop, Bethesda, MD, March 12 and 13, 2005
Griffith, LM
Pavletic, SZ
Tyndall, A
Bredeson, CN
Bowen, JD
Childs, RW
Gratwohl, A
van Laar, JM
Mayes, MD
Martin, R
McSweeney, PA
Muraro, PA
Openshaw, H
Saccardi, R
Sandmaier, BM
Forman, SJ
Nash, RA
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (11) : 862 - 870
[5] HANDA T, 2004, J CLIN HEMATOL, V45, P135
[6] Autologous hematopoietic stem-cell transplantation for Behcet's disease with pulmonary involvement.
Hensel, M
Breitbart, A
Ho, AD
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (01) : 69 - 69
[7] Haemopoietic stem cell transplantation in autoimmune diseases: a European perspective
Hough, RE
Snowden, JA
Wulffraat, NM
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 (04) : 432 - 459
[8] Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis - Behcet's syndrome
Kimura, S
Kuroda, J
Akaogi, T
Hayashi, H
Kobayashi, Y
Kondo, M
[J]. LEUKEMIA & LYMPHOMA, 2001, 42 (1-2) : 115 - 121
[9] Autologous haematopoietic stem cell transplantation for Behcet's disease with pulmonary involvement: analysis after 5 years of follow up
Maurer, B
Hensel, M
Max, R
Fiehn, C
Ho, AD
Lorenz, HM
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (01) : 127 - 129
[10] NIWA Y, 1982, CLIN EXP IMMUNOL, V49, P247

← 1 2 →