Increased Intrinsic Connectivity of the Default Mode Network in Temporal Lobe Epilepsy: Evidence from Resting-State MEG Recordings

被引：55

作者：

Hsiao, Fu-Jung ^{[1
,5
,6
,7
]}

Yu, Hsiang-Yu ^{[2
,8
]}

Chen, Wei-Ta ^{[1
,2
,7
,8
]}

Kwan, Shang-Yeong ^{[2
,8
]}

Chen, Chien ^{[2
,8
]}

Yen, Der-Jen ^{[2
,8
]}

Yiu, Chun-Hing ^{[2
,8
]}

Shih, Yang-Hsin ^{[1
,2
,9
]}

Lin, Yung-Yang ^{[1
,2
,3
,4
,5
,7
,8
]}

机构：

[1] Natl Yang Ming Univ, Sch Med, Inst Brain Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Dept Neurol, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Inst Clin Med, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Inst Physiol, Taipei 112, Taiwan

[5] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan

[6] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan

[7] Taipei Vet Gen Hosp, Div Med Res, Lab Neurophysiol Med, Taipei, Taiwan

[8] Taipei Vet Gen Hosp, Dept Neurol, Taipei, Taiwan

[9] Taipei Vet Gen Hosp, Dept Neurosurg, Taipei, Taiwan

来源：

PLOS ONE | 2015年 / 10卷 / 06期

关键词：

ALTERED FUNCTIONAL CONNECTIVITY; GRAPH-THEORETICAL ANALYSIS; ALZHEIMERS-DISEASE; GENERALIZED SPIKE; CINGULATE CORTEX; DELTA-ACTIVITY; BOLD SIGNAL; SMALL-WORLD; BRAIN; FMRI;

D O I：

10.1371/journal.pone.0128787

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The electrophysiological signature of resting state oscillatory functional connectivity within the default mode network (DMN) during spike-free periods in temporal lobe epilepsy (TLE) remains unclear. Using magnetoencephalographic (MEG) recordings, this study investigated how the connectivity within the DMN was altered in TLE, and we examined the effect of lateralized TLE on functional connectivity. Sixteen medically intractable TLE patients and 22 controls participated in this study. Whole-scalp 306-channel MEG epochs without interictal spikes generated from both MEG and EEG data were analyzed using a minimum norm estimate (MNE) and source-based imaginary coherence analysis. With this processing, we obtained the cortical activation and functional connectivity within the DMN. The functional connectivity was increased between DMN and the right medial temporal (MT) region at the delta band and between DMN and the bilateral anterior cingulate cortex (ACC) regions at the theta band. The functional change was associated with the lateralization of TLE. The right TLE showed enhanced DMN connectivity with the right MT while the left TLE demonstrated increased DMN connectivity with the bilateral MT. There was no lateralization effect of TLE upon the DMN connectivity with ACC. These findings suggest that the resting-state functional connectivity within the DMN is reinforced in temporal lobe epilepsy during spike-free periods. Future studies are needed to examine if the altered functional connectivity can be used as a biomarker for treatment responses, cognitive dysfunction and prognosis in patients with TLE.

引用

页数：18

共 96 条

[1] FMRI "deactivation" of the posterior cingulate during generalized spike and wave [J].