Importance of Rho-kinase-mediated phosphorylation of myosin light chain in vasospasm

被引：0

作者：

Sato, M ^{[1
]}

Tani, E ^{[1
]}

Fujikawa, H ^{[1
]}

Yamaura, I ^{[1
]}

Arita, N ^{[1
]}

Kaibuchi, K ^{[1
]}

机构：

[1] Hyogo Med Univ, Nishinomiya, Hyogo, Japan

来源：

CEREBRAL VASOSPASM | 2001年 / 77卷

关键词：

vasospasm; Rho-kinase; myosin light chain;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Subarachnoid hemorrhage often induces a longterm narrowing of cerebral artery called vasospasm. Rho-kinase is activated by the small GTPase Rho which phosphorylates not only MLC but also myosin phosphatase at its subunit (myosin binding subunit; MBS). The present study examined 1) an activation of Rho-A and Rho-kinase in vasospasm, 2) phosphorylation of myosin binding subunit (MBS; a subunit of myosin phosphatase) in the basilar artery involved in development of vasospasm. 3) Whether these activities and phosphorylations are inhibited by kinase inhibitors (Y-27632, wortmannin, genistein)?.

引用

页码：49 / 54

页数：6

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