Comparative Cytotoxicity Study of Water-Soluble Carbon Nanoparticles on Plant Cells

被引：14

作者：

Dang, Song ^{[1
]}

Liu, Qiaoling ^{[1
]}

Zhang, Xuejie ^{[1
]}

He, Kangmin ^{[1
,2
,3
]}

Wang, Chunru ^{[1
]}

Fang, Xiaohong ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Peking Univ, Inst Vasc Med, Hosp 3,Minist Educ,Key Lab Mol Cardiovasc Sci, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Beijing 100191, Peoples R China

[3] Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2012年 / 12卷 / 06期

关键词：

Single-Walled Carbon Nanotubes; Fullerenes; Cytotoxicity; Fluorescence Imaging; BY-2; Cells; ACTIN CYTOSKELETON; OXIDATIVE STRESS; NANOMATERIALS; NANOTUBES; DEATH; ARABIDOPSIS; TOXICITY; RICE;

D O I：

10.1166/jnn.2012.6216

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study provides a parallel cytotoxicity study of water-soluble single-walled carbon nanotubes and fullerene C-70(C(COOH)(2))(4-8) on Nicotiana tabacum BY-2 cells. After BY-2 cells were treated with single-walled carbon nanotubes or C-70(C(COOH)(2))(4-8), the cells adopted a shrunken morphology and exhibited lower proliferation rate. Fluorescence imaging of the treated cells revealed increased reactive oxygen species generation, abnormal mitochondrial distribution, decreased mitochondrial activity, and impaired actin cytoskeleton arrangement. However, no obvious cells death was induced by either single-walled carbon nanotubes or C-70(C(COOH)(2))(4-8). Compared with single-walled carbon nanotubes, C-70(C(COOH)(2))(4-8) exerted more serious adverse effects on BY-2 cells.

引用

页码：4478 / 4484

页数：7

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