Regulation of metabolism: the circadian clock dictates the time

被引：156

作者：

Sahar, Saurabh ^{[1
]}

Sassone-Corsi, Paolo ^{[1
]}

机构：

[1] Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92697 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 01期

基金：

美国国家卫生研究院;

关键词：

REV-ERB-ALPHA; ARNT-LIKE PROTEIN-1; RECIPROCAL REGULATION; GLUCOSE-HOMEOSTASIS; HEME-BIOSYNTHESIS; NUCLEAR RECEPTORS; MAMMALIAN CLOCK; MOLECULAR CLOCK; SHIFT WORK; TRANSCRIPTION;

D O I：

10.1016/j.tem.2011.10.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circadian rhythms occur with a periodicity of approximately 24 h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.

引用

页码：1 / 8

页数：8

共 84 条

[1] The hypocretins as sensors for metabolism and arousal [J].

Adamantidis, Antoine ;

de Lecea, Luis .

JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (01) :33-40

[2] Control of intracellular dynamics of mammalian period proteins by casein kinase I ε (CKIε) and CKIδ in cultured cells [J].

Akashi, M ;

Tsuchiya, Y ;

Yoshino, T ;

Nishida, E .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (06) :1693-1703

[3] Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus [J].

Akhtar, RA ;

Reddy, AB ;

Maywood, ES ;

Clayton, JD ;

King, VM ;

Smith, AG ;

Gant, TW ;

Hastings, MH ;

Kyriacou, CP .

CURRENT BIOLOGY, 2002, 12 (07) :540-550

[4] Regulation of intracellular levels of NAD: A novel role for CD38 [J].

Aksoy, Pinar ;

White, Thomas A. ;

Thompson, Michael ;

Chini, Eduardo N. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (04) :1386-1392

[5] Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology [J].

Alenghat, Theresa ;

Meyers, Katherine ;

Mullican, Shannon E. ;

Leitner, Kirstin ;

Adeniji-Adele, Adetoun ;

Avila, Jacqueline ;

Bucan, Maja ;

Ahima, Rexford S. ;

Kaestner, Klaus H. ;

Lazar, Mitchell A. .

NATURE, 2008, 456 (7224) :997-U88

[6] Circadian Timing of Food Intake Contributes to Weight Gain [J].

Arble, Deanna M. ;

Bass, Joseph ;

Laposky, Aaron D. ;

Vitaterna, Martha H. ;

Turek, Fred W. .

OBESITY, 2009, 17 (11) :2100-2102

[7] SIRT1 regulates circadian clock gene expression through PER2 deacetylation [J].

Asher, Gad ;

Gatfield, David ;

Stratmann, Markus ;

Reinke, Hans ;

Dibner, Charna ;

Kreppel, Florian ;

Mostoslavsky, Raul ;

Alt, Frederick W. ;

Schibler, Ueli .

CELL, 2008, 134 (02) :317-328

[8]

BROWN MS, 1979, J BIOL CHEM, V254, P5144

[9] Mop3 is an essential component of the master circadian pacemaker in mammals [J].

Bunger, MK ;

Wilsbacher, LD ;

Moran, SM ;

Clendenin, C ;

Radcliffe, LA ;

Hogenesch, JB ;

Simon, MC ;

Takahashi, JS ;

Bradfield, CA .

CELL, 2000, 103 (07) :1009-1017

[10] Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor α defines a novel positive feedback loop in the rodent liver circadian clock [J].

Canaple, Laurence ;

Rambaud, Juliette ;

Dkhissi-Benyahya, Ouria ;

Rayet, Beatrice ;

Tan, Nguan Soon ;

Michalik, Liliane ;

Delaunay, Franck ;

Wahli, Walter ;

Laudet, Vincent .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (08) :1715-1727

← 1 2 3 4 5 6 7 8 9 →