The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

被引：342

作者：

Liu, Tao ^{[1
]}

Liu, Pei Y. ^{[1
]}

Marshall, Glenn M. ^{[1
,2
]}

机构：

[1] Childrens Canc Inst Australia Med Res, Sydney, NSW, Australia

[2] Sydney Childrens Hosp, Ctr Childrens Canc & Blood Disorders, Sydney, NSW, Australia

来源：

CANCER RESEARCH | 2009年 / 69卷 / 05期

基金：

英国医学研究理事会;

关键词：

REGULATES SIRT1; P53; MOUSE;

D O I：

10.1158/0008-5472.CAN-08-3365

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene expression and deacetylase activity of the class III histone deacetylase SIRT1 are up-regulated in cancer cells due to oncogene overexpression or loss of function of tumor suppressor genes. SIRT1 induces histone deacetylation and methylation, promoter CpG island methylation, transcriptional repression, and deacetylation of tumor suppressor proteins. SIRT1 may play a critical role in tumor initiation, progression, and drug resistance by blocking senescence and apoptosis, and promoting cell growth and angiogenesis. SIRT1 inhibitors have shown promising anticancer effects in animal models of cancer. Further screening for more potent SIRT1 inhibitors may lead to compounds suitable for clinical trials in patients. [Cancer Res 2009;69(5):1702-5]

引用

页码：1702 / 1705

页数：4

共 20 条

[1] Phosphorylation of HuR by Chk2 regulates SIRT1 expression
Abdelmohsen, Kotb
Pullmann, Rudolf, Jr.
Lai, Ashish
Kim, Hyeon Ho
Galban, Stefanie
Yang, Xiaoling
Blethrow, Justin D.
Walker, Mark
Shubert, Jonathan
Gillespie, David A.
Furneaux, Henry
Gorospe, Myriam
[J]. MOLECULAR CELL, 2007, 25 (04) : 543 - 557
[2] Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
Chen, WY
Wang, DH
Yen, RWC
Luo, JY
Gu, W
Baylin, SB
[J]. CELL, 2005, 123 (03) : 437 - 448
[3] Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1
Chu, F
Chou, PM
Zheng, X
Mirkin, BL
Rebbaa, A
[J]. CANCER RESEARCH, 2005, 65 (22) : 10183 - 10187
[4] Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells
Dey, Swatee
Bakthavatchalu, Vasudevan
Tseng, Michael T.
Wu, Peng
Florence, Rebecca L.
Grulke, Eric A.
Yokel, Robert A.
Dhar, Sanjit Kumar
Yang, Hsin-Sheng
Chen, Yumin
Clair, Daret K. St
[J]. CARCINOGENESIS, 2008, 29 (10) : 1920 - 1929
[5] Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
Heltweg, B
Gatbonton, T
Schuler, AD
Posakony, J
Li, HZ
Goehle, S
Kollipara, R
DePinho, RA
Gu, YS
Simon, JA
Bedalov, A
[J]. CANCER RESEARCH, 2006, 66 (08) : 4368 - 4377
[6] SIRT1 is significantly elevated in mouse and human prostate cancer
Huffman, Derek M.
Grizzle, William E.
Bamman, Marcas M.
Kim, Jeong-su
Eltoum, Isam A.
Elgavish, Ada
Nagy, Tim R.
[J]. CANCER RESEARCH, 2007, 67 (14) : 6612 - 6618
[7] Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
Kim, Eun-Joo
Kho, Jeong-Hoon
Kang, Moo-Rim
Um, Soo-Jong
[J]. MOLECULAR CELL, 2007, 28 (02) : 277 - 290
[8] Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
Lain, Sonia
Hollick, Jonathan J.
Campbell, Johanna
Staples, Oliver D.
Higgins, Maureen
Aoubala, Mustapha
McCarthy, Anna
Appleyard, Virginia
Murray, Karen E.
Baker, Lee
Thompson, Alastair
Mathers, Joanne
Holland, Stephen J.
Stark, Michael J. R.
Pass, Georgia
Woods, Julie
Lane, David P.
Westwood, Nicholas J.
[J]. CANCER CELL, 2008, 13 (05) : 454 - 463
[9] Analysis of gene expression and chemoresistance of CDI33+ cancer stem cells in glioblastoma
Liu, Gentao
Yuan, Xiangpeng
Zeng, Zhaohui
Tunici, Patrizia
Ng, Hiushan
Abdulkadir, Iman R.
Lu, Lizhi
Irvin, Dwain
Black, Keith L.
Yu, John S.
[J]. MOLECULAR CANCER, 2006, 5 (1)
[10] Negative control of p53 by Sir2α promotes cell survival under stress
Luo, JY
Nikolaev, AY
Imai, S
Chen, DL
Su, F
Shiloh, A
Guarente, L
Gu, W
[J]. CELL, 2001, 107 (02) : 137 - 148

← 1 2 →