Wall teichoic acid is an essential component of Staphylococcus aureus for the induction of human dendritic cell maturation

被引：9
作者：
Hong, Sung Jun [1 ,2 ,6 ]
Kim, Sun Kyung [1 ,2 ]
Ko, Eun Byeol [1 ,2 ]
Yun, Cheol-Heui [3 ,4 ,5 ]
Han, Seung Hyun [1 ,2 ]
机构：
[1] Seoul Natl Univ, DRI, Dept Oral Microbiol & Immunol, Sch Dent, Bldg 86,1 Gwanak Ro, Seoul 08826, South Korea
[2] Seoul Natl Univ, Sch Dent, Plus Program BK21, Bldg 86,1 Gwanak Ro, Seoul 08826, South Korea
[3] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 08826, South Korea
[4] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea
[5] Seoul Natl Univ, Inst Green Bio Sci Technol, Pyeongchang 25354, South Korea
[6] Mogam Inst Biomed Res, 93 Ihyeon Ro 30 Beon Gil, Yongin 16924, Gyeonggi Do, South Korea
来源：
MOLECULAR IMMUNOLOGY | 2017年 / 81卷
基金：
新加坡国家研究基金会;
关键词：
Staphylococcus aureus; Wall teichoic acid; Mutant; Dendritic cell; Maturation; T cell activation; MANNOSE-BINDING LECTIN; GRAM-POSITIVE BACTERIA; TUMOR-NECROSIS-FACTOR; NOSOCOMIAL INFECTIONS; RESPONSES; SURFACE; POLYSACCHARIDE; COLONIZATION; PHAGOCYTOSIS; PATHOGENESIS;
D O I：
10.1016/j.molimm.2016.12.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Staphylococcus aureus is a Gram-positive pathogen that can cause chronic skin inflammation, pneumonia, and septic shock. The immunomodulatory functions of wall teichoic acid (WTA), a glycopolymer abundantly expressed on the Gram-positive bacterial cell wall, are poorly understood. Here, we investigated the role of WTA in the phenotypic and functional activation of human monocyte-derived dendritic cells (DCs) treated with ethanol-killed S. aureus. WTA-deficient S. aureus mutant (Delta tagO) exhibited attenuated binding and internalization to DCs compared to the wild-type. Delta tagO induced lower expression of maturation markers on and cytokines in DCs than the wild-type S. aureus. Furthermore, autologous human peripheral blood mononuclear cells cocultured with Delta tagO-treated DCs exhibited a marked reduction in T cell proliferative activity, the expression of activation markers, and the production of cytokines compared to the wild-type S. aureus-stimulated DCs. Collectively, these results suggest that WTA is an important cell wall component of S. aureus for the induction of DC maturation and activation. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：135 / 142
页数：8
相关论文
共 43 条
  • [1] Wall Teichoic Acids of Staphylococcus aureus Limit Recognition by the Drosophila Peptidoglycan Recognition Protein-SA to Promote Pathogenicity
    Atilano, Magda L.
    Yates, James
    Glittenberg, Marcus
    Filipe, Sergio R.
    Ligoxygakis, Petros
    [J]. PLOS PATHOGENS, 2011, 7 (12)
  • [2] Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids
    Brown, Stephanie
    Xia, Guoqing
    Luhachack, Lyly G.
    Campbell, Jennifer
    Meredith, Timothy C.
    Chen, Calvin
    Winstel, Volker
    Gekeler, Cordula
    Irazoqui, Javier E.
    Peschel, Andreas
    Walker, Suzanne
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (46) : 18909 - 18914
  • [3] Polysaccharide processing and presentation by the MHCII pathway
    Cobb, BA
    Wang, O
    Tzianabos, AO
    Kasper, DL
    [J]. CELL, 2004, 117 (05) : 677 - 687
  • [4] Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens
    Cobb, BA
    Kasper, DL
    [J]. CELLULAR MICROBIOLOGY, 2005, 7 (10) : 1398 - 1403
  • [5] NASAL, AXILLARY, AND PERINEAL CARRIAGE OF STAPHYLOCOCCUS-AUREUS AMONG WOMEN - IDENTIFICATION OF STRAINS PRODUCING EPIDERMOLYTIC TOXIN
    DANCER, SJ
    NOBLE, WC
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1991, 44 (08) : 681 - 684
  • [6] Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers
    Datta, Rupak
    Huang, Susan S.
    [J]. CLINICAL INFECTIOUS DISEASES, 2008, 47 (02) : 176 - 181
  • [7] PHAGOCYTOSIS OF ANTIGEN A CRUCIAL STEP IN INDUCTION OF PRIMARY RESPONSE
    FREI, PC
    BENACERR.B
    THORBECK.GJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 53 (01) : 20 - &
  • [8] Key role of teichoic acid net charge in Staphylococcus aureus colonization of artificial surfaces
    Gross, M
    Cramton, SE
    Götz, F
    Peschel, A
    [J]. INFECTION AND IMMUNITY, 2001, 69 (05) : 3423 - 3426
  • [9] Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development
    Holland, Linda M.
    Conlon, Brian
    O'Gara, James P.
    [J]. MICROBIOLOGY-SGM, 2011, 157 : 408 - 418
  • [10] Phagocytosis and Phagosome Acidification Are Required for Pathogen Processing and MyD88-Dependent Responses to Staphylococcus aureus
    Ip, W. K. Eddie
    Sokolovska, Anna
    Charriere, Guillaume M.
    Boyer, Laurent
    Dejardin, Stephanie
    Cappillino, Michael P.
    Yantosca, L. Michael
    Takahashi, Kazue
    Moore, Kathryn J.
    Lacy-Hulbert, Adam
    Stuart, Lynda M.
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 184 (12) : 7071 - 7081
12345