Direct infusion mass spectrometry for metabolomic phenotyping of diseases

被引：69
作者：
Gonzalez-Dominguez, Raul [1 ,2 ]
Sayago, Ana [1 ,2 ]
Fernandez-Recamales, Angeles [1 ,2 ]
机构：
[1] Univ Huelva, Fac Expt Sci, Dept Chem, Huelva 21007, Spain
[2] Univ Huelva, Int Campus Excellence CeiA3, Huelva 21007, Spain
来源：
BIOANALYSIS | 2017年 / 9卷 / 01期
关键词：
Alzheimer's disease; cancer; diabetes; direct infusion; flow injection; mass spectrometry; metabolomics; obesity; APP/PS1 TRANSGENIC MODEL; EARLY ALZHEIMERS-DISEASE; FREE FATTY-ACIDS; BIOMARKER DISCOVERY; HIGH-THROUGHPUT; LUNG-CANCER; DIAGNOSTIC BIOMARKERS; QUANTITATIVE-ANALYSIS; DIABETIC MYOCARDIUM; SERUM METABOLOMICS;
D O I：
10.4155/bio-2016-0202
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabolomics based on direct mass spectrometry (MS) analysis, either by direct infusion or flow injection of crude sample extracts, shows a great potential for metabolic fingerprinting because of its high-throughput screening capability, wide metabolite coverage and reduced time of analysis. Considering that numerous metabolic pathways are significantly perturbed during the initiation and progression of diseases, these metabolomic tools can be used to get a deeper understanding about disease pathogenesis and discover potential biomarkers for early diagnosis. In this work, we describe the most common metabolomic platforms used in biomedical research, with special focus on strategies based on direct MS analysis. Then, a comprehensive review on the application of direct MS fingerprinting in clinical issues is provided.
引用
收藏
页码：131 / 148
页数：18
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