Direct infusion mass spectrometry for metabolomic phenotyping of diseases

被引：68
作者：
Gonzalez-Dominguez, Raul [1 ,2 ]
Sayago, Ana [1 ,2 ]
Fernandez-Recamales, Angeles [1 ,2 ]
机构：
[1] Univ Huelva, Fac Expt Sci, Dept Chem, Huelva 21007, Spain
[2] Univ Huelva, Int Campus Excellence CeiA3, Huelva 21007, Spain
来源：
BIOANALYSIS | 2017年 / 9卷 / 01期
关键词：
Alzheimer's disease; cancer; diabetes; direct infusion; flow injection; mass spectrometry; metabolomics; obesity; APP/PS1 TRANSGENIC MODEL; EARLY ALZHEIMERS-DISEASE; FREE FATTY-ACIDS; BIOMARKER DISCOVERY; HIGH-THROUGHPUT; LUNG-CANCER; DIAGNOSTIC BIOMARKERS; QUANTITATIVE-ANALYSIS; DIABETIC MYOCARDIUM; SERUM METABOLOMICS;
D O I：
10.4155/bio-2016-0202
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabolomics based on direct mass spectrometry (MS) analysis, either by direct infusion or flow injection of crude sample extracts, shows a great potential for metabolic fingerprinting because of its high-throughput screening capability, wide metabolite coverage and reduced time of analysis. Considering that numerous metabolic pathways are significantly perturbed during the initiation and progression of diseases, these metabolomic tools can be used to get a deeper understanding about disease pathogenesis and discover potential biomarkers for early diagnosis. In this work, we describe the most common metabolomic platforms used in biomedical research, with special focus on strategies based on direct MS analysis. Then, a comprehensive review on the application of direct MS fingerprinting in clinical issues is provided.
引用
收藏
页码：131 / 148
页数：18
相关论文
共 124 条
  • [1] Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support
    Ahmad, Tariq
    Kelly, Jacob P.
    McGarrah, Robert W.
    Hellkamp, Anne S.
    Fiuzat, Mona
    Testani, Jeffrey M.
    Wang, Teresa S.
    Verma, Amanda
    Samsky, Marc D.
    Donahue, Mark P.
    Ilkayeva, Olga R.
    Bowles, Dawn E.
    Patel, Chetan B.
    Milano, Carmelo A.
    Rogers, Joseph G.
    Felker, G. Michael
    O'Connor, Christopher M.
    Shah, Svati H.
    Kraus, William E.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (03) : 291 - 299
  • [2] Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status
    Allam-Ndoul, Benedicte
    Guenard, Frederic
    Garneau, Veronique
    Cormier, Hubert
    Barbier, Olivier
    Perusse, Louis
    Vohl, Marie-Claude
    [J]. NUTRIENTS, 2016, 8 (06)
  • [3] Detection and confirmation of serum lipid biomarkers for preeclampsia using direct infusion mass spectrometry
    Anand, Swati
    Young, Sydney A.
    Esplin, M. Sean
    Peaden, Benjamin
    Tolley, H. Dennis
    Porter, T. Flint
    Varner, Michael W.
    D'Alton, Mary E.
    Jackson, Bruce J.
    Graves, Steven W.
    [J]. JOURNAL OF LIPID RESEARCH, 2016, 57 (04) : 687 - 696
  • [4] Ion suppression in mass spectrometry
    Annesley, TM
    [J]. CLINICAL CHEMISTRY, 2003, 49 (07) : 1041 - 1044
  • [5] Metabolic Signatures of Triatomine Vectors of Trypanosoma cruzi Unveiled by Metabolomics
    Antunes, Luis Caetano M.
    Han, Jun
    Pan, Jingxi
    Moreira, Carlos J. C.
    Azambuja, Patricia
    Borchers, Christoph H.
    Carels, Nicolas
    [J]. PLOS ONE, 2013, 8 (10):
  • [6] Capillary electrophoresis as a metabolomics tool for non-targeted fingerprinting of biological samples
    Barbas, C.
    Moraes, Edgar P.
    Villasenor, A.
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2011, 55 (04) : 823 - 831
  • [7] High-throughput, nontargeted metabolite fingerprinting using nominal mass flow injection electrospray mass spectrometry
    Beckmann, Manfred
    Parker, David
    Enot, David P.
    Duval, Emilie
    Draper, John
    [J]. NATURE PROTOCOLS, 2008, 3 (03) : 486 - 504
  • [8] Beecher CWW, 2003, METABOLIC PROFILING: ITS ROLE IN BIOMARKER DISCOVERY AND GENE FUNCTION ANALYSIS, P311
  • [9] The metabolomic detection of lung cancer biomarkers in sputum
    Cameron, Simon J. S.
    Lewis, Keir E.
    Beckmann, Manfred
    Allison, Gordon G.
    Ghosal, Robin
    Lewis, Paul D.
    Mur, Luis A. J.
    [J]. LUNG CANCER, 2016, 94 : 88 - 95
  • [10] A biochemical perspective on the use of tandem mass spectrometry for newborn screening and clinical testing
    Chace, DH
    Kalas, TA
    [J]. CLINICAL BIOCHEMISTRY, 2005, 38 (04) : 296 - 309
12345678910