The upsurge in the need of targeted controlled drug delivery ( TCDD) has led to the invention of remarkable biomaterials with improved biocompatibility and biodegradability. In recent years, "Smart Polymers" have emerged as a potential candidate, competing with the existing hydrogel systems used for controlled drug delivery. This article is an effort to highlight the diverse applications of hydrogels for revolutionizing the present research on drug delivery systems. This article summarizes the role of hydrogels as delivery vehicles for drugs used in various disorders related to the brain and other distinct parts of the human body. The clinical application and toxicological aspects of hydrogels are also highlighted. Their potential for diagnostics and various therapeutic interventions against tuberculosis have been reviewed. In addition, the limitations and future prospectives in the development of biopolymeric hydrogels are discussed.
机构:
Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USABoston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Liu, Boya
Chen, Kuo
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Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USABoston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
机构:
Rush Univ, Med Ctr, Dept Pharmacol, Chicago, IL 60612 USAAcad Pharmaceut Inc, Lake Bluff, IL 60044 USA
Lin, Congrong
Sunkara, Gangadhar
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Novartis Pharmaceut, Exploratory Dev, E Hanover, NJ USAAcad Pharmaceut Inc, Lake Bluff, IL 60044 USA
Sunkara, Gangadhar
Cannon, John B.
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机构:Acad Pharmaceut Inc, Lake Bluff, IL 60044 USA
Cannon, John B.
Ranade, Vasant
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机构:
Acad Pharmaceut Inc, Lake Bluff, IL 60044 USA
Rush Univ, Med Ctr, Dept Pharmacol, Chicago, IL 60612 USAAcad Pharmaceut Inc, Lake Bluff, IL 60044 USA