Suppressive Actions of Astragali Radix (AR) Ethanol Extract and Isolated Astragaloside I on HCl/ethanol-induced Gastric Lesions

被引：9
作者：
Jeong, Jeong Suk [1 ]
Lee, Je-Hyuk [2 ]
Lee, Sang Hyup [1 ]
Kang, Sam Sik [3 ]
Jeong, Choon Sik [1 ]
机构：
[1] Duksung Womens Univ, Coll Pharm, Seoul 132714, South Korea
[2] Duksung Womens Univ, Plant Resources Res Inst, Seoul 132714, South Korea
[3] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2009年 / 17卷 / 01期
关键词：
Astragalus membranaceus; Astragali Radix (AR); Astragaloside I; Gastritis; Helicobacter pylori; HELICOBACTER-PYLORI; MEMBRANACEUS; PROSTAGLANDINS; INHIBITION; MECHANISMS; INFECTION; ISCHEMIA; SAPONINS; CELLS; VITRO;
D O I：
10.4062/biomolther.2009.17.1.62
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Roots of Astragalus membranaceus (A. membranaceus) (Astragali Radix, AR) has been used as a herbal medicine for gastrointestinal disorders in China, Korea, Japan, and other Asia countries. In this study we investigated the effects of the AR 70% ethanol extract and compounds isolated from AR on gastritis in rats and growth of human gastric cancer cells. AR 70% ethanol extract showed the potent acid-neutralizing capacities and partly cytotoxicity of Helicobacter pylori and human AGS gastric cancers cell. Astragaloside I and daucosterol, which were isolated from AR, significantly inhibited HCl/ethanol-induced gastric lesions. In addition, daucosterol increased the mucus content to almost the same as the positive control. The results of this study suggest that astragaloside I and daucosterol may be good candidates for the development of new drugs or neutraceuticals which can be used for the treatment or prevention of gastritis.
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收藏
页码：62 / 69
页数：8
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