New synthetic route to granulatimide and its structural analogues

被引：26

作者：

Yoshida, T ^{[1
]}

Nishiyachi, M ^{[1
]}

Nakashima, N ^{[1
]}

Murase, M ^{[1
]}

Kotani, E ^{[1
]}

机构：

[1] Showa Pharmaceut Univ, Tokyo 1948543, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 06期

关键词：

alkaloid; indole; maleimide; imidazole; Stille coupling reaction; synthesis;

D O I：

10.1248/cpb.50.872

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Stille coupling reaction of stannylindole 12 with 4-iodoimidazole 13 (or 24) in the presence of PdCl2(PPh3)(2) gave the corresponding indole-imidazole coupling product 14 (or 25), thereby affording a new synthetic approach to the alkaloid granulatimide (7), isolated from the Brazilian ascidian Didemnum granulatum, as well as its structural analogues, 10-methylgranulatimide (23), 17-methylgranulatimide (30), 10,17-dimethylgranulatimide (31).

引用

页码：872 / 876

页数：5

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