Clinical, endoscopic, and histologic characteristics of lymphocytic esophagitis: a systematic review

被引：14

作者：

Habbal, Mohamad ^{[1
]}

Scaffidi, Michael A. ^{[1
]}

Rumman, Amir ^{[1
]}

Khan, Rishad ^{[1
]}

Ramaj, Mirusha ^{[1
]}

Al-Mazroui, Ahmed ^{[1
]}

Abunassar, Michael J. ^{[1
]}

Jeyalingam, Thurarshen ^{[1
]}

Shetty, Akshay ^{[1
]}

Kandel, Gabor P. ^{[1
]}

Streutker, Catherine J. ^{[2
]}

Grover, Samir C. ^{[1
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Div Gastroenterol, Dept Med, 30 Bond St,16-036 Cardinal Carter Wing, Toronto, ON M5B 1W8, Canada

[2] Univ Toronto, St Michaels Hosp, Dept Lab Med, Toronto, ON, Canada

来源：

ESOPHAGUS | 2019年 / 16卷 / 02期

关键词：

Lymphocytic esophagitis; Dysphagia; Gastroesophageal reflux disease (GERD); Diagnostic criteria; GASTROESOPHAGEAL-REFLUX DISEASE; T-CELL PREDOMINANCE; EOSINOPHILIC ESOPHAGITIS; CONSENSUS RECOMMENDATIONS; BARRETTS-ESOPHAGUS; ADULT PATIENTS; CASE SERIES; DIAGNOSIS; DYSPHAGIA; CHILDREN;

D O I：

10.1007/s10388-018-0649-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

ObjectiveLymphocytic esophagitis (LyE) is a novel, yet poorly described, clinicopathologic entity. The aim of this systematic review was to characterize the demographic, clinical, endoscopic, and histologic features of LyE in observational studies of adult and pediatric patients.DesignWe searched the Embase, MEDLINE, and SCOPUS databases for relevant studies in 2018. Two authors reviewed and extracted data from studies that met the inclusion and exclusion criteria.ResultsWe identified 20 studies for analysis of demographic, clinical, and endoscopic features of LyE. The mean age ranged from 9 to 67years. When pooled, there were 231 (52.7%) patients with LyE that were female. The most common presenting symptom was dysphagia reported in 191 (48.8%) patients. On endoscopy, most patients with LyE tended to have abnormal findings (69.0%), which included erosive esophagitis, multiple esophageal rings, linear furrows, and narrow-caliber esophagus. In the 31 studies used to assess the histologic definition, the cut-off number of intraepithelial lymphocytes (IELs) was reported in 16 (51.6%) studies, peripapillary IEL specification in 18 (58.1%) studies, and presence of spongiosis in 6 (19.4%) studies.ConclusionWe identified a spectrum of demographic, clinical, and endoscopic findings characteristic of patients with LyE. A consensus on the diagnostic criteria of LyE is required.

引用

页码：123 / 132

页数：10

共 80 条

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