Intratubular Germ Cell Neoplasia of the Testis, Bilateral Testicular Cancer, and Aberrant Histologies

被引:9
作者
Sharma, Pranav [1 ]
Dhillon, Jasreman [2 ]
Sexton, Wade J. [1 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Oncol, Tampa, FL 33612 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Anat Pathol, Tampa, FL 33612 USA
关键词
CARCINOMA-IN-SITU; INTRAEPITHELIAL NEOPLASIA; CONTRALATERAL TESTIS; CLINICAL-OUTCOMES; HISTOPATHOLOGICAL ABNORMALITIES; MICROLITHIASIS PREDICTS; SPARING SURGERY; TUMORS; RISK; MEN;
D O I
10.1016/j.ucl.2015.04.002
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Intratubular germ cell neoplasia (ITGCN) is a precursor lesion for testicular germ cell tumors, most of which are early stage. ITGCN is also associated with testicular cancer or ITGCN in the contralateral testis, leading to a risk of bilateral testicular malignancy. Testicular biopsy detects most cases, and orchiectomy is the treatment of choice in patients with unilateral ITGCN. Low-dose radiation therapy is recommended in patients with bilateral ITGCN or ITGCN in the solitary testis, but the long-term risks of infertility and hypogonadism need to be discussed with the patient. Rare histologies of primary testicular cancer are also discussed.
引用
收藏
页码:277 / +
页数:10
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