First total synthesis of natural pulsatilla saponin D via highly stereospecific glycosylation

被引：12

作者：

Kim, Minkyu ^{[1
]}

Lim, Eunyoung ^{[1
]}

Jung, Mankil ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

TETRAHEDRON | 2013年 / 69卷 / 26期

关键词：

Pulsatilla saponin D; Stereospecific glycosylation; Total synthesis; Trisaccharide; Hederagenin; TRITERPENOID SAPONINS; FACILE SYNTHESIS; ANTITUMOR-ACTIVITY; OLIGOSACCHARIDES; ACTIVATION; GLYCOSIDES; KOREANA; MOIETY;

D O I：

10.1016/j.tet.2013.04.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of pulsatilla saponin D, a potent anti-lung cancer natural product was accomplished in eight steps from L-arabinopyranoside in high overall yield via a highly stereospecific glycosylation featuring an oxocarbenium mechanism between the trisaccharide derivative and aglycone as the key step. (C) 2013 Elsevier Ltd. All rights reserved.

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收藏

页码：5481 / 5486

页数：6

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