Characterisation and mechanisms of bradykinin-evoked pain in man using iontophoresis

被引:24
作者
Paterson, Kathryn J. [1 ]
Zambreanu, Laura [1 ]
Bennett, David L. H. [2 ]
McMahon, Stephen B. [1 ]
机构
[1] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England
[2] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
关键词
Pain; Bradykinin; Des-Arg9-bradykinin; Iontophoresis; Mast cell; SKIN MAST-CELLS; B-1; RECEPTORS; HYPERALGESIA; SENSITIZATION; HISTAMINE; ACTIVATION; EXPRESSION; RESPONSES; FLARE; WHEAL;
D O I
10.1016/j.pain.2013.01.003
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Bradykinin (BK) is an inflammatory mediator that can evoke oedema and vasodilatation, and is a potent algogen signalling via the B1 and B2 G-protein coupled receptors. In naive skin, BK is effective via constitutively expressed B2 receptors (B2R), while B1 receptors (B1R) are purported to be upregulated by inflammation. The aim of this investigation was to optimise BK delivery to investigate the algesic effects of BK and how these are modulated by inflammation. BK iontophoresis evoked dose-and temperature-dependent pain and neurogenic erythema, as well as thermal and mechanical hyperalgesia (P < 0.001 vs saline control). To differentiate the direct effects of BK from indirect effects mediated by histamine released from mast cells (MCs), skin was pretreated with compound 4880 to degranulate the MCs prior to BK challenge. The early phase of BK-evoked pain was reduced in degranulated skin (P < 0.001), while thermal and mechanical sensitisation, wheal, and flare were still evident. In contrast to BK, the B1R selective agonist des-Arg9-BK failed to induce pain or sensitise naive skin. However, following skin inflammation induced by ultraviolet B irradiation, this compound produced a robust pain response. We have optimised a versatile experimental model by which BK and its analogues can be administered to human skin. We have found that there is an early phase of BK-induced pain which partly depends on the release of inflammatory mediators by MCs; however, subsequent hyperalgesia is not dependent on MC degranulation. In naive skin, B2R signaling predominates, however, cutaneous inflammation results in enhanced B1R responses. (C) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:782 / 792
页数:11
相关论文
共 45 条
[21]   Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain [J].
Borgonetti, Vittoria ;
Morozzi, Martina ;
Galeotti, Nicoletta .
NEUROPHARMACOLOGY, 2024, 259
[22]   Assessment of endothelial function in complex regional pain syndrome type I using iontophoresis and laser Doppler imaging [J].
Gorodkin, R ;
Moore, T ;
Herrick, A .
RHEUMATOLOGY, 2004, 43 (06) :727-730
[23]   Granger Causality-Based Pain Classification Using EEG Evoked by Electrical Stimulation Targeting Nociceptive Aδ and C Fibers [J].
Tripanpitak, Kornkanok ;
He, Siyu ;
Sonmezisik, Ilker ;
Morant, Thibaut ;
Huang, Shao Ying ;
Yu, Wenwei .
IEEE ACCESS, 2021, 9 :10089-10106
[24]   The effect of pain conditioning on experimentally evoked cough: evidence of impaired endogenous inhibitory control mechanisms in refractory chronic cough [J].
Hilton, Emma ;
Satia, Imran ;
Holt, Kimberley ;
Woodcock, Ashley A. ;
Belcher, John ;
Smith, Jaclyn A. .
EUROPEAN RESPIRATORY JOURNAL, 2020, 56 (06)
[25]   Mechanisms of intracerebral pain and itch perception in humans using neuroimaging methods [J].
Kakigi, Ryusuke .
PAIN RESEARCH, 2012, 27 (04) :203-214
[26]   A bioadaptive approach for experimental pain research in humans using laser-evoked brain potentials [J].
Weiss, T ;
Kumpf, K ;
Ehrhardt, J ;
Gutberlet, I ;
Miltner, WHR .
NEUROSCIENCE LETTERS, 1997, 227 (02) :95-98
[27]   Prediction of Pain Perception using Multivariate Pattern Analysis of Laser-evoked EEG Oscillations [J].
Tu, Yiheng ;
Hung, Yeung Sam ;
Zhang, Zhiguo ;
Hu, Li .
2014 13TH INTERNATIONAL CONFERENCE ON CONTROL AUTOMATION ROBOTICS & VISION (ICARCV), 2014, :13-16
[28]   Pain management using photobiomodulation: Mechanisms, location, and repeatability quantified by pain threshold and neural biomarkers in mice [J].
Pires de Sousa, Marcelo Victor ;
Kawakubo, Masayoshi ;
Ferraresi, Cleber ;
Kaippert, Beatriz ;
Yoshimura, Elisabeth Mateus ;
Hamblin, Michael R. .
JOURNAL OF BIOPHOTONICS, 2018, 11 (07)
[29]   Development of a Stimulator for the Characterization of Mechanical-Evoked Pain-Related Supra-Spinal Processing Using BOLD-fMRI in Rodents [J].
Just, Nathalie ;
Segelcke, Daniel ;
Sandbrink, Martin ;
Pogatzki-Zahn, Esther ;
Faber, Cornelius .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2020, 67 (05) :1349-1356
[30]   Assessing the Effects of the Topical Application of L-Menthol on Pain-Related Somatosensory-Evoked Potentials Using Intra-Epidermal Stimulation [J].
Makibuchi, Taiki ;
Yamashiro, Koya ;
Anazawa, Sayaka ;
Fujimoto, Tomomi ;
Ochi, Genta ;
Ikarashi, Koyuki ;
Sato, Daisuke .
BRAIN SCIENCES, 2023, 13 (06)