Apoptosis in atherosclerosis: A mini-review

被引：24

作者：

Karaflou, Maria ^{[1
]}

Lambrinoudaki, Irene ^{[1
]}

Christodoulakos, George ^{[1
]}

机构：

[1] Univ Athens, Aretaieion Hosp, Dept Obstet & Gynecol 2, Athens, Greece

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 09期

关键词：

atherosclerosis; apoptosis; pathogenesis;

D O I：

10.2174/138955708785132765

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

引用

页码：912 / 918

页数：7

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