Stability of Cefoselis Sulfate in Intravenous Solutions

The stability of cefoselis sulfate in various intravenous solutions was studied. 20 mg mL(-1) solutions of cefoselis sulfate were prepared by using a variety of intravenous diluents and stored in poly(vinyl chloride) minibags for up to 24 h at room temperature (20 degrees C) and at 5 degrees C and for up to 30 days at -20 degrees C. Cefoselis sulfate concentrations were determined by high-performance liquid chromatography. The stability of cefoselis sulfate was affected to the highest degree by storage temperature, composition of intravenous solutions used as diluents and the concentrations of their components. When cefoselis sulfate was stored for 24 h in glucose solution (5 and 10 %) at room temperature, its stability was above 99.5 % of the initial value whereas the medium of mannitol reduced its concentration to 91.6 % after only 2 h.