Effect of Preoperative Diabetes Management on Glycemic Control and Clinical Outcomes After Elective Surgery

被引:91
作者
Garg, Rajesh [1 ]
Schuman, Brooke [1 ]
Bader, Angela [2 ]
Hurwitz, Shelley [1 ]
Turchin, Alexander [1 ,3 ]
Underwood, Patricia [4 ]
Metzger, Cheyenne [1 ]
Rein, Raquel [1 ]
Lortie, Meghan [1 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, 221 Longwood Ave, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesia Pain & Perioperat Med, Boston, MA USA
[3] Baim Inst Clin Res, Boston, MA USA
[4] Vet Adm Hosp, Boston, MA USA
关键词
elective surgery; length of hospital stay; postoperative outcomes; preoperative diabetes management; INTENSIVE INSULIN THERAPY; PERIOPERATIVE OUTCOMES; HYPERGLYCEMIA; INFECTIONS; RISK; MELLITUS; OBESITY; IMPACT;
D O I
10.1097/SLA.0000000000002323
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: The aim of this study was to evaluate whether preoperative diabetes management can improve glycemic control and clinical outcomes after elective surgery. Background: There is lack of data on the importance of diabetes treatment before elective surgery. Diabetes is often ignored before surgery and aggressively treated afterwards. Methods: Patients with diabetes were identified and treated proactively before their scheduled surgeries. Data for all elective surgeries over 2 years before and 2 years after implementation of the program were collected. Results: Out of 31,392 patients undergoing first surgery, 3909 had diabetes; 2072 before and 1835 after the program. Mean blood glucose on the day of surgery was 146.4 +/- 51.9 mg/dL before and 139.9 +/- 45.6 mg/dL after the program (P = 0.0028). Proportion of patients seen by the inpatient diabetes team increased. Mean blood glucose during hospital stay was 166.7 +/- 42.9 mg/dL before and 158.3 +/- 46.6 mg/dL after program (P < 0.0001). The proportion of patients with hypoglycemic episodes (< 50 mg/dL) was 4.93% before and 2.48% after the program (P < 0.0001). Length of hospital stay (LOS) decreased among patients with diabetes (4.8 +/- 5.3 to 4.6 +/- 4.3 days; P = 0.01) and remained unchanged among patients without diabetes (4.0 +/- 4.5 and 4.1 +/- 4.8, respectively; P = 0.42). Changes in intravenous antibiotic use, patients discharged to home, renal insufficiency, myocardial infarction, stroke, and in-hospital mortality were similar among diabetic and nondiabetic groups. Conclusions: Preoperative and inpatient diabetes management improves glycemic control on the day of surgery and postoperatively and decreases the incidence of hypoglycemia. These changes may eventually improve clinical outcomes. Although statistically significant, the decrease in LOS was of equivocal clinical significance in this study.
引用
收藏
页码:858 / 862
页数:5
相关论文
共 32 条
[1]   POLYMORPHONUCLEAR LEUKOCYTES IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS - ABNORMALITIES IN METABOLISM AND FUNCTION [J].
ALEXIEWICZ, JM ;
KUMAR, D ;
SMOGORZEWSKI, M ;
KLIN, M ;
MASSRY, SG .
ANNALS OF INTERNAL MEDICINE, 1995, 123 (12) :919-+
[2]   The impact of hyperglycemia and obesity on hospitalization costs and clinical outcome in general surgery patients [J].
Buehler, Lauren ;
Fayfman, Maya ;
Alexopoulos, Anastasia-Stefania ;
Zhao, Liping ;
Farrokhi, Farnoosh ;
Weaver, Jeff ;
Smiley-Byrd, Dawn ;
Pasquel, Francisco J. ;
Vellanki, Priyathama ;
Umpierrez, Guillermo E. .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2015, 29 (08) :1177-1182
[3]   Increased hospital expenditures in diabetic patients hospitalized for cardiovascular diseases [J].
Carral, F ;
Aguilar, M ;
Olveira, G ;
Mangas, A ;
Doménech, I ;
Torres, I .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2003, 17 (06) :331-336
[4]   VALIDATION OF A COMBINED COMORBIDITY INDEX [J].
CHARLSON, M ;
SZATROWSKI, TP ;
PETERSON, J ;
GOLD, J .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 1994, 47 (11) :1245-1251
[5]   NHS Diabetes guideline for the perioperative management of the adult patient with diabetes [J].
Dhatariya, K. ;
Levy, N. ;
Kilvert, A. ;
Watson, B. ;
Cousins, D. ;
Flanagan, D. ;
Hilton, L. ;
Jairam, C. ;
Leyden, K. ;
Lipp, A. ;
Lobo, D. ;
Sinclair-Hammersley, M. ;
Rayman, G. .
DIABETIC MEDICINE, 2012, 29 (04) :420-433
[6]   The Role of Chronic and Perioperative Glucose Management in High-Risk Surgical Closures: A Case for Tighter Glycemic Control [J].
Endara, Matthew ;
Masden, Derek ;
Goldstein, Jesse ;
Gondek, Stephen ;
Steinberg, John ;
Attinger, Christopher .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2013, 132 (04) :996-1004
[7]   Intensive versus Conventional Glucose Control in Critically Ill Patients [J].
Finfer, S. ;
Blair, D. ;
Bellomo, R. ;
McArthur, C. ;
Mitchell, I. ;
Myburgh, J. ;
Norton, R. ;
Potter, J. ;
Chittock, D. ;
Dhingra, V. ;
Foster, D. ;
Cook, D. ;
Dodek, P. ;
Hebert, P. ;
Henderson, W. ;
Heyland, D. ;
McDonald, E. ;
Ronco, J. ;
Schweitzer, L. ;
Peto, R. ;
Sandercock, P. ;
Sprung, C. ;
Young, J. D. ;
Su, S. ;
Heritier, S. ;
Li, Q. ;
Bompoint, S. ;
Billot, L. ;
Crampton, L. ;
Darcy, F. ;
Jayne, K. ;
Kumarasinghe, V. ;
Little, L. ;
McEvoy, S. ;
MacMahon, S. ;
Pandey, S. ;
Ryan, S. ;
Shukla, R. ;
Vijayan, B. ;
Atherton, S. ;
Bell, J. ;
Hadfield, L. ;
Hourigan, C. ;
McArthur, C. ;
Newby, L. ;
Simmonds, C. ;
Buhr, H. ;
Eccleston, M. ;
McGuinness, S. ;
Parke, R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) :1283-1297
[8]   The association between hemoglobin A1C values and deep sternal wound infections in diabetes patients undergoing cardiac surgery [J].
Fohl, Alexander L. ;
Butler, Simona O. ;
Patil, Preethi V. ;
Zrull, Christina A. ;
Kling-Colson, Sue ;
Dubois, Elizabeth ;
Sweeney, Jennifer L. ;
Haft, Jonathan W. ;
Gianchandani, Roma Y. .
CARDIOVASCULAR ENDOCRINOLOGY, 2013, 2 (01) :15-22
[9]  
Fraze T., 2010, Hospital stays for patients with diabetes
[10]   Prevalence and Clinical Outcome of Hyperglycemia in the Perioperative Period in Noncardiac Surgery [J].
Frisch, Anna ;
Chandra, Prakash ;
Smiley, Dawn ;
Peng, Limin ;
Rizzo, Monica ;
Gatcliffe, Chelsea ;
Hudson, Megan ;
Mendoza, Jose ;
Johnson, Rachel ;
Lin, Erica ;
Umpierrez, Guillermo E. .
DIABETES CARE, 2010, 33 (08) :1783-1788