HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

被引：109

作者：

Janakiram, Murali ^{[1
,2
]}

Chinai, Jordan M. ^{[1
]}

Zhao, Aimin ^{[3
]}

Sparano, Joseph A. ^{[2
]}

Zang, Xingxing ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA

[2] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, Bronx, NY 10467 USA

[3] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Obstet & Gynecol, Shanghai 200030, Peoples R China

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 08期

关键词：

angiogenesis; B7; family; CD28; HHLA2; immunosuppression; immunotherapy; ligand; receptor; tumor microenvironment; TMIGD2; IDENTIFICATION; MEMBER;

D O I：

10.1080/2162402X.2015.1026534

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We and others recently discovered HHLA2 as a new B7 family member and transmembrane and immunoglobulin domain containing 2 (TMIGD2) as one of its receptors. Based on a new study we propose that HHLA2 may represent a novel immunosuppressive mechanism within the tumor microenvironment and hence could be a target for cancer therapy. TMIGD2 may be another therapeutic target.

引用

页数：3

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