Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET

被引：9

作者：

Ko, Ji Hyun ^{[1
,2
]}

Koshimori, Yuko ^{[1
,2
]}

Mizrahi, Romina ^{[1
]}

Rusjan, Pablo ^{[1
]}

Wilson, Alan A. ^{[1
]}

Lang, Anthony E. ^{[2
,3
]}

Houle, Sylvain ^{[1
]}

Strafella, Antonio P. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON M5T 2S8, Canada

[2] Univ Toronto, Toronto Western Res Inst, UHN, Div Brain Imaging & Behav Syst Neurosci, Toronto, ON M5T 2S8, Canada

[3] Univ Toronto, Toronto Western Hosp, EJ Safra Program Parkinson Dis, UHN,Movement Disorder Unit, Toronto, ON M5T 2S8, Canada

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2013年 / 33卷 / 03期

基金：

加拿大健康研究院;

关键词：

inflammation; kinetic modeling; microglia; neurooncology; positron emission tomography; PERIPHERAL BENZODIAZEPINE-RECEPTORS; POSITRON-EMISSION-TOMOGRAPHY; GRAPHICAL ANALYSIS; HUMAN BRAIN; RADIOLIGAND; BINDING; MICROGLIA; TUMORS; LIGAND;

D O I：

10.1038/jcbfm.2012.203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vivo imaging of translocator protein 18kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an F-18-labeled TSPO ligand, [F-18]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [F-18]-FEPPA total distribution volume. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 348-350; doi:10.1038/jcbfm.2012.203; published online 2 January 2013

引用

页码：348 / 350

页数：3

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