Intermittent parathyroid hormone 1-34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone

被引：6
作者：
Yoshioka, Yohsuke [1 ]
Yamachika, Eiki [2 ]
Nakanishi, Makoto [3 ]
Ninomiya, Tadashi [4 ]
Akashi, Sho [1 ]
Kondo, Sei [1 ]
Moritani, Norifumi [1 ]
Kobayashi, Yasuhiro [5 ]
Fujii, Tatsuo [3 ]
Iida, Seiji [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral & Maxillofacial Reconstruct Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama, Japan
[2] Okayama Univ Hosp, Dept Oral & Maxillofacial Reconstruct Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama, Japan
[3] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Appl Chem, Kita Ku, 1-1-1 Tsushima Naka, Okayama, Japan
[4] Nihon Univ, Sch Dent, Dept Anat, Chiyoda Ku, 1-8-13 Kanda Surugadai, Tokyo, Japan
[5] Matsumoto Dent Univ, Inst Oral Sci, Div Hard Tissue Res, 1780 Gobara Hirooka, Nagano, Japan
来源：
SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期
关键词：
OSTEOPOROSIS; MECHANISMS; INCREASES; MELATONIN; STRENGTH; IMPLANTS; THERAPY;
D O I：
10.1038/s41598-019-44389-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.
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页数：10
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