Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

被引：17

作者：

Almeida, S. S. ^{[1
]}

Naffah-Mazzacoratti, M. G. ^{[2
,3
]}

Guimaraes, P. B. ^{[1
]}

Wasinski, F. ^{[1
]}

Pereira, F. E. G. ^{[1
]}

Canzian, M. ^{[4
]}

Centeno, R. S. ^{[4
]}

Carrete, H. ^{[4
]}

Yacubian, E. M. ^{[4
]}

Carmona, A. K. ^{[1
]}

Vieira, R. F. F. ^{[1
]}

Nakaie, C. R. ^{[1
]}

Sabatini, R. A. ^{[1
]}

Perosa, S. R. ^{[2
,3
]}

Bacurau, R. F. P. ^{[5
]}

Gouveia, T. L. F. ^{[2
,3
]}

Gallo, G. ^{[6
]}

Wuertele, M. ^{[6
]}

Cavalheiro, E. A. ^{[2
,3
]}

Silva, J. A., Jr. ^{[7
]}

Pesquero, J. B. ^{[1
]}

Araujo, R. C. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Biophys, BR-04023032 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, BR-04023032 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Dept Pathol, BR-04023032 Sao Paulo, Brazil

[4] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04023032 Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil

[6] Univ Fed Sao Paulo, Dept Sci & Technol, BR-04023032 Sao Paulo, Brazil

[7] Nove de Julho Univ UNINOVE, Dept Rehabil Sci, Sao Paulo, Brazil

来源：

TRANSLATIONAL PSYCHIATRY | 2012年 / 2卷

基金：

巴西圣保罗研究基金会;

关键词：

angiotensin I-converting enzyme; carbamazepine; epilepsy; TLE; SYSTEM; BRAIN; POLYMORPHISM; HIPPOCAMPUS;

D O I：

10.1038/tp.2012.21

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012

引用

页码：e93 / e93

页数：5

共 14 条

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