Copper-free Sonogashira reaction using 7-chloro camptothecins

被引：22
作者：
Luo, Y
Gao, HY
Li, YF
Huang, WG
Lu, W
Zhang, ZG
机构：
[1] Chinese Acad Sci, Grad Sch, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
来源：
TETRAHEDRON | 2006年 / 62卷 / 11期
关键词：
camptothecin; topoisomerase; 1; Sonogashira coupling; palladium; catalysis;
D O I：
10.1016/j.tet.2006.01.001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We studied copper-free Sonogashira reaction using 7-chloro camptothecins, and determined that rac-BINAP/Pd(OAc)(2) was an efficient catalyst for the coupling reaction. With this process, a number of 7-substituted camptothecins with a wide range of functional groups are potentially accessible. Besides, two drugs, SN-38 and BNP-1350, Could be prepared by this method. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2465 / 2470
页数：6
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