Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi

被引：9
作者：
Pan, Zheng-Hong [1 ]
Cheng, Ling [1 ]
Ning, De-Sheng [1 ]
Peng, Li-Yan [2 ]
Fu, Yu-Xia [1 ]
Li, Lian-Chun [1 ]
机构：
[1] Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2019年 / 30卷
关键词：
Illicium difengpi; Difengpienol A; Difengpienol B; Sesqui-neolignans; Anti-inflammatory; CONSTITUENTS; PERICARPS; SIMONSII;
D O I：
10.1016/j.phytol.2019.02.023
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
As part of our ongoing search for novel and bioactive natural products in Karst plants, two new sesqui-neolignans, difengpienol A (1) and difengpienol B (2), together with two known analogues (3 and 4), were isolated from the stem bark of Illicium difengpi. Their structures were elucidated by analysis of spectroscopic data. Difengpienol A (1) possessed a unique 1, 4-dibenzodioxocine moiety. All isolates were evaluated for inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages cells. Compounds 1 and 2 showed moderate inhibitory effects on NO production with IC50 values of 16.9 and 23.8 mu M. A biosynthetic pathway was also proposed for 1 and 2.
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页码：210 / 214
页数：5
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