Ligand binding by repeat proteins: natural and designed

被引：98

作者：

Grove, Tijana Z. ^{[1
]}

Cortajarena, Aitziber L. ^{[1
]}

Regan, Lynne ^{[1
,2
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.sbi.2008.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Repeat proteins contain tandem arrays of small structural motifs. As a consequence of this architecture, they adopt non-globular, extended structures that present large, highly specific surfaces for ligand binding. Here we discuss recent advances toward understanding the functional role of this unique modular architecture. We showcase specific examples of natural repeat proteins interacting with diverse ligands and also present examples of designed repeat protein-ligand interactions.

引用

页码：507 / 515

页数：9

共 36 条

[1] High-affinity binders selected from designed ankyrin repeat protein libraries [J].

Binz, HK ;

Amstutz, P ;

Kohl, A ;

Stumpp, MT ;

Briand, C ;

Forrer, P ;

Grütter, MG ;

Plückthun, A .

NATURE BIOTECHNOLOGY, 2004, 22 (05) :575-582

[2] Structure-based design of a pathway-specific nuclear import inhibitor [J].

Cansizoglu, Ahmet E. ;

Lee, Brittany J. ;

Zhang, Zi Chao ;

Fontoura, Beatriz M. A. ;

Chook, Yuh Min .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (05) :452-454

[3] Structural basis of PP2A inhibition by small t antigen [J].

Cho, Uhn Soo ;

Morrone, Seamus ;

Sablina, Anna A. ;

Arroyo, Jason D. ;

Hahn, William C. ;

Xu, Wenqing .

PLOS BIOLOGY, 2007, 5 (08) :1810-1819

[4] Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme [J].

Cho, Uhn Soo ;

Xu, Wenqing .

NATURE, 2007, 445 (7123) :53-57

[5] Structure of the nuclear transport complex karyopherin-β2-Ran•GppNHp [J].

Chook, YM ;

Blobel, G .

NATURE, 1999, 399 (6733) :230-237

[6] Designed TPR modules as novel anticancer agents [J].

Cortajarena, Aitziber L. ;

Yi, Fang ;

Regan, Lynne .

ACS CHEMICAL BIOLOGY, 2008, 3 (03) :161-166

[7] Ligand binding by TPR domains [J].

Cortajarena, AL ;

Regan, L .

PROTEIN SCIENCE, 2006, 15 (05) :1193-1198

[8] Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins [J].

Cortajarena, AL ;

Kajander, T ;

Pan, WL ;

Cocco, MJ ;

Regan, L .

PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (04) :399-409

[9] Molecular recognition of histone H3 by the WD40 protein WDR5 [J].

Couture, Jean-Francois ;

Collazo, Evys ;

Trievel, Raymond C. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (08) :698-703

[10] The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions [J].

Das, AK ;

Cohen, PTW ;

Barford, D .

EMBO JOURNAL, 1998, 17 (05) :1192-1199

← 1 2 3 4 →