Lower incidence of de novo donor-specific antibodies against HLA-DR in ABO-incompatible renal transplantation

被引：5

作者：

Okada, Manabu ^{[1
,2
]}

Watarai, Yoshihiko ^{[1
]}

Iwasaki, Kenta ^{[3
]}

Futamura, Kenta ^{[4
]}

Yamamoto, Takayuki ^{[1
]}

Hiramitsu, Takahisa ^{[1
]}

Tsujita, Makoto ^{[4
]}

Goto, Norihiko ^{[4
]}

Narumi, Shunji ^{[1
]}

Takeda, Asami ^{[5
]}

Kobayashi, Takaaki ^{[2
]}

机构：

[1] Nagoya Daini Red Cross Hosp, Kidney Dis Ctr, Dept Transplant Surg, Showa Ku, 2-9 Myoken Cho, Nagoya, Aichi 4668650, Japan

[2] Aichi Med Univ, Sch Med, Dept Renal Transplant Surg, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[3] Aichi Med Univ, Sch Med, Dept Kidney Dis & Transplant Immunol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[4] Nagoya Daini Red Cross Hosp, Kidney Dis Ctr, Dept Transplant Internal Med, Showa Ku, 2-9 Myoken Cho, Nagoya, Aichi 4668650, Japan

[5] Nagoya Daini Red Cross Hosp, Kidney Dis Ctr, Dept Nephrol, Showa Ku, 2-9 Myoken Cho, Nagoya, Aichi 4668650, Japan

来源：

HUMAN IMMUNOLOGY | 2019年 / 80卷 / 03期

基金：

日本学术振兴会;

关键词：

ABO incompatible renal transplantation; De novo DSA; CLASS-I ANTIBODY; KIDNEY-TRANSPLANTATION; ENDOTHELIAL-CELLS; MEDIATED REJECTION; EXPRESSION; ACCOMMODATION; COMPLEMENT; A/B;

D O I：

10.1016/j.humimm.2018.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, in vitro experiments have demonstrated that anti-blood group A/B antibody binding to endothelial cells induce a protective effect against antibody-mediated injury. This study aimed to clarify the potential clinical benefit of ABO incompatibility in donor-specific HLA antibody (DSA)-induced chronic antibody-mediated rejection (ABMR). We enrolled 215 ABO-incompatible renal transplant (ABO-I) and 467 ABO-identical/compatible renal transplant recipients (ABO-Id/C). The prevalence of de novo DSA production and incidence of biopsy-proven chronic ABMR were compared between the two groups. The incidence of DR-associated de novo DSA was significantly lower in ABO-I than in ABO-Id/C (P = 0.028). Diagnostic biopsy for ABMR was conducted in 54 patients (11 ABO-I and 43 ABO-Id/C). Biopsy-proven chronic ABMR was lower in ABO-I than in ABO-Id/C (27.3% [3/11] vs. 44.2% [19/43]) patients. Our findings suggest that ABO incompatibility may cause low production of DR-associated de novo DSA, possibly resulting in a reduced incidence of chronic ABMR.

引用

页码：169 / 175

页数：7

共 27 条

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