Parvovirus Diversity and DNA Damage Responses

被引:52
作者
Cotmore, Susan F. [1 ]
Tattersall, Peter [1 ,2 ]
机构
[1] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
基金
美国国家卫生研究院;
关键词
MINUTE VIRUS; HUMAN BOCAVIRUSES; PROTEIN NS1; P4; PROMOTER; REPLICATION; MICE; GENOME; B19; INFECTION; BINDING;
D O I
10.1101/cshperspect.a012989
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an evolutionary adaptation of rolling-circle synthesis in which the hairpins create duplex replication origins, prime complementary strand synthesis, and act as hinges to reverse the direction of the unidirectional cellular fork. Genomes are packaged vectorially into small, rugged protein capsids similar to 260 angstrom in diameter, which mediate their delivery directly into the cell nucleus, where they await their host cell's entry into S phase under its own cell cycle control. Here we focus on genus-specific variations in genome structure and replication, and review host cell responses that modulate the nuclear environment.
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页数:12
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