Structural, conformational and pharmacological study of some amides derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9β-amine as potential analgesics

被引：3

作者：

Iriepa, I

Gil-Alberdi, B

Gálvez, E

Herranz, MJ

Bellanato, J

Carmona, P

Orjales, A

Berisa, A

Labeaga, L

机构：

[1] Univ Alcala de Henares, Dept Quim Organ, Madrid, Spain

[2] CSIC, Inst Estructura Mat, E-28006 Madrid, Spain

[3] Labs FAES SA, Bilbao, Spain

来源：

JOURNAL OF MOLECULAR STRUCTURE | 1999年 / 482卷

关键词：

3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 beta-amine; vibrational spectroscopy; NMR spectroscopy;

D O I：

10.1016/S0022-2860(98)00945-4

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of amides derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 beta-amine were synthesized and studied by IR, Raman,H-1 and C-13 NMR spectroscopy The compounds studied displayed in CDCl3 a preferred flattened chair-chair conformation. IR (at room and variable temperature) and H-1 and C-13 NMR data showed the presence of an intramolecular NH ... N-heterocyclic hydrogen bond in the pirazine derivative (TV). Pharmacological assays on mice were drawn to evaluate drug-induced behavioral alteration peripheral or central acute toxicity and analgesic activity. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：425 / 430

页数：6

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