[Bmim]OH mediated Cu-catalyzed azide-alkyne cycloaddition reaction: A potential green route to 1,4-disubstituted 1,2,3-triazoles

被引：32

作者：

Ali, Abdul Aziz ^{[1
]}

Konwar, Manashjyoti ^{[1
]}

Chetia, Mitali ^{[1
]}

Sarma, Diganta ^{[1
]}

机构：

[1] Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 50期

关键词：

Bmim]OH; Azide; Alkyne; 1,2,3-Triazoles; Green chemistry; BASIC IONIC LIQUID; 1,3-DIPOLAR CYCLOADDITIONS; MICHAEL ADDITION; CLICK CHEMISTRY; MATERIALS SCIENCE; ORGANIC-SYNTHESIS; N-HETEROCYCLES; EFFICIENT; PROTOCOL; SOLVENT;

D O I：

10.1016/j.tetlet.2016.11.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work, a task-specific ionic liquid 1-methyl-3-butylimidazolium hydroxide [Bmim]OH has been used as a potential greener solvent for Cu-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and provides a simple way to access 1,4-disubstituted 1,2,3-triazoles regioselectively with excellent yields, without requiring bases, reducing agents, ligands or inert atmosphere. Moreover, a one-pot three component CuAAC reaction was developed using alkyl bromide, sodium azide, and terminal alkyne affording 1,2,3-triazoles in high yields. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5661 / 5665

页数：5

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