Corticosteroids, the aging brain and cognition

被引：74
作者：
McEwen, BS
de Leon, MJ
Lupien, SJ
Meaney, MJ
机构：
[1] Rockefeller Univ, New York, NY 10021 USA
[2] NYU, Sch Med, Dept Psychiat, Neuroimaging Lab, New York, NY 10016 USA
[3] McGill Univ, Douglas Hosp, Res Ctr, Lab Psychoneuroendocrine Res, Verdun, PQ H4H 1R3, Canada
[4] Geriatr Inst Montreal, Lab Psychoneuorendocrine Res, Montreal, PQ H3W 1W5, Canada
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 03期
关键词：
D O I：
10.1016/S1043-2760(98)00122-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The hippocampal region of the brain is a useful model system for understanding the plasticity and resilience of brain cells to stress hormone action and aging. Hippocampal neurons show both structural and functional plasticity, and individual differences in hippocampal function are shaped by early life experiences. For human brain aging, there are new non-invasive imaging fools to relate to the animal models, and these, can help to assess the vulnerability of the aging hippocampus in relation to stress and Alzheimer's disease.
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页码：92 / 96
页数：5
相关论文
共 39 条
[1]  
Cameron H. A, 1996, RECEPTOR DYNAMICS NE, P141
[2]   PROGENY OF MOTHERS DRINKING CORTICOSTERONE DURING LACTATION HAS LOWER STRESS-INDUCED CORTICOSTERONE SECRETION AND BETTER COGNITIVE PERFORMANCE [J].
CATALANI, A ;
MARINELLI, M ;
SCACCIANOCE, S ;
NICOLAI, R ;
MUSCOLO, LAA ;
PORCU, A ;
KORANYI, L ;
PIAZZA, PV ;
ANGELUCCI, L .
BRAIN RESEARCH, 1993, 624 (1-2) :209-215
[3]   HIPPOCAMPAL VOLUME LOSSES IN MINIMALLY IMPAIRED ELDERLY [J].
CONVIT, A ;
DELEON, MJ ;
TARSHISH, C ;
DESANTI, S ;
KLUGER, A ;
RUSINEK, H ;
GEORGE, AE .
LANCET, 1995, 345 (8944) :266-266
[4]   Brain corticosteroid receptor balance in health and disease [J].
De Kloet, ER ;
Vreugdenhil, E ;
Oitzl, MS ;
Joëls, M .
ENDOCRINE REVIEWS, 1998, 19 (03) :269-301
[5]   Stress and glucocorticoids impair retrieval of long-term spatial memory [J].
de Quervain, DJF ;
Roozendaal, B ;
McGaugh, JL .
NATURE, 1998, 394 (6695) :787-790
[6]   Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease [J].
deLeon, MJ ;
McRae, T ;
Rusinek, H ;
Convit, A ;
DeSanti, S ;
Tarshish, C ;
Golomb, J ;
Volkow, N ;
Daisley, K ;
Orentreich, N ;
McEwen, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (10) :3251-3259
[7]  
DELEON MJ, 1983, AM J NEURORADIOL, V4, P568
[8]  
DELEON MJ, 1989, LANCET, V2, P672
[9]   Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease [J].
deLeon, MJ ;
George, AE ;
Golomb, J ;
Tarshish, C ;
Convit, A ;
Kluger, A ;
DeSanti, S ;
McRae, T ;
Ferris, SH ;
Reisberg, B ;
Ince, C ;
Rusinek, H ;
Bobinski, M ;
Quinn, B ;
Miller, DC ;
Wisniewski, HM .
NEUROBIOLOGY OF AGING, 1997, 18 (01) :1-11
[10]  
DELEON MJ, 1993, AM J NEURORADIOL, V14, P897
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