Epinephrine (adrenaline) absorption from new-generation, taste-masked sublingual tablets: A preclinical study

被引:12
作者
Rachid, Ousama [1 ]
Rawas-Qalaji, Mutasem M. [4 ]
Simons, F. Estelle R. [2 ,3 ]
Simons, Keith J. [1 ,2 ]
机构
[1] Univ Manitoba, Fac Pharm, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Fac Med, Dept Pediat & Child Hlth, Winnipeg, MB R3T 2N2, Canada
[3] Univ Manitoba, Fac Med, Dept Immunol, Winnipeg, MB R3T 2N2, Canada
[4] Nova SE Univ, Coll Pharm, Ft Lauderdale, FL 33314 USA
关键词
ANAPHYLAXIS; INJECTION; ADULTS;
D O I
10.1016/j.jaci.2012.10.016
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:236 / 238
页数:4
相关论文
共 9 条
[1]   Epinephrine 0.3 mg Bioavailability Following a Single Injection with a Novel Epinephrine Auto-injector, e-cue™, in Healthy Adults, with Reference to a Single Injection using EpiPen® 0.3 mg [J].
Edwards, E. S. ;
Gunn, R. ;
Simons, E. F. ;
Carr, K. ;
Chinchilli, V. M. ;
Painter, G. ;
Goldwater, R. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (02) :AB179-AB179
[2]   Epinephrine absorption in adults: Intramuscular versus subcutaneous injection [J].
Estelle, F ;
Simons, R ;
Gu, XC ;
Simons, KJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :871-873
[3]  
Rachid O, 2012, EUR J PHARM BIOPHARM
[4]   An Electronic Tongue: Evaluation of the Masking Efficacy of Sweetening and/or Flavoring Agents on the Bitter Taste of Epinephrine [J].
Rachid, Ousama ;
Simons, F. Estelle R. ;
Rawas-Qalaji, Mutasem ;
Simons, Keith J. .
AAPS PHARMSCITECH, 2010, 11 (02) :550-557
[5]   Sublingual epinephrine tablets versus intramuscular injection of epinephrine: Dose equivalence for potential treatment of anaphylaxis [J].
Rawas-Qalaji, MM ;
Simons, FER ;
Simons, KJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) :398-403
[6]   Anaphylaxis in the community: Learning from the survivors [J].
Simons, F. Estelle R. ;
Clark, Sunday ;
Camargo, Carlos A., Jr. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (02) :301-306
[7]   Epinephrine absorption in children with a history of anaphylaxis [J].
Simons, FER ;
Roberts, JR ;
Gu, XC ;
Simons, KJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (01) :33-37
[8]   Epinephrine and its use in anaphylaxis: current issues [J].
Simons, Keith J. ;
Simons, F. Estelle R. .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 10 (04) :354-361
[9]   Effect of epinephrine on platelet-activating factor-stimulated human vascular smooth muscle cells [J].
Vadas, Peter ;
Perelman, Boris .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (05) :1329-1333