Heart rate variability - a historical perspective

被引:396
作者
Billman, George E. [1 ]
机构
[1] Ohio State Univ, Dept Physiol & Cell Biol, Columbus, OH 43210 USA
关键词
heart rate variability; respiratory sinus arrhythmia; time domain; frequency domain; autonomic nervous system; RESPIRATORY SINUS ARRHYTHMIA; SUDDEN CARDIAC DEATH; FRACTAL CORRELATION-PROPERTIES; FREQUENCY-DOMAIN MEASURES; LEFT-VENTRICULAR FUNCTION; POWER SPECTRAL-ANALYSIS; RATE MULTISCALE ENTROPY; PULMONARY GAS-EXCHANGE; RATE DYNAMICS; RATE RECOVERY;
D O I
10.3389/fphys.2011.00086
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Heart rate variability (HRV), the beat-to-beat variation in either heart rate or the duration of the R-R interval - the heart period, has become a popular clinical and investigational tool. The temporal fluctuations in heart rate exhibit a marked synchrony with respiration (increasing during inspiration and decreasing during expiration - the so called respiratory sinus arrhythmia, RSA) and are widely believed to reflect changes in cardiac autonomic regulation. Although the exact contributions of the parasympathetic and the sympathetic divisions of the autonomic nervous system to this variability are controversial and remain the subject of active investigation and debate, a number of time and frequency domain techniques have been developed to provide insight into cardiac autonomic regulation in both health and disease. It is the purpose of this essay to provide an historical overview of the evolution in the concept of HRV. Briefly, pulse rate was first measured by ancient Greek physicians and scientists. However, it was not until the invention of the "Physician's Pulse Watch" (a watch with a second hand that could be stopped) in 1707 that changes in pulse rate could be accurately assessed. The Rev. Stephen Hales (1733) was the first to note that pulse varied with respiration and in 1847 Carl Ludwig was the first to record RSA. With the measurement of the ECG (1895) and advent of digital signal processing techniques in the 1960s, investigation of HRV and its relationship to health and disease has exploded. This essay will conclude with a brief description of time domain, frequency domain, and non-linear dynamic analysis techniques (and their limitations) that are commonly used to measure HRV.
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页数:13
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