Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts

被引：40

作者：

Kim, Sangmin ^{[1
,3
]}

Chung, Jin Ho ^{[1
,2
,3
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul, South Korea

[2] Seoul Natl Univ Hosp, Dept Dermatol, Clin Res Inst, Lab Cutaneous Aging Res, Seoul 110744, South Korea

[3] Seoul Natl Univ, Med Res Ctr, Inst Dermatol Sci, Seoul, South Korea

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 09期

关键词：

berberine; MMP-1; type I procollagen; human dermal fibroblast; UV irradiation;

D O I：

10.1016/j.phymed.2007.11.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation. Therefore, regulation of these genes has been suggested to be a useful tool to abolish skin aging. In this study, antioxidative plant ingredients used in traditional Chinese medicine, berberine (BBR) was investigated for their capacity to regulate MMP-1 and type I procollagen expression in human dermal fibroblasts. Our results showed that both basal and UV-induced MMP-1 expression was decreased by BBR. On the other hand, type I procollagen expression was dose-dependently increased by it. In addition, UV-induced reduction of type I procollagen expression is recovered by it. Therefore, we suggest that BBR may be a possible candidate for anti-skin aging agent. (C) 2007 Elsevier GmbH. All rights reserved.

引用

页码：749 / 753

页数：5

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