The safety and clinical efficacy of recombinant human granulocyte colony stimulating factor injection for colon cancer patients undergoing chemotherapy

被引：5
作者：
Chen, Jie [1 ,3 ]
Pan, Yin [2 ,3 ]
机构：
[1] Northern Jiangsu Peoples Hosp, Yangzhou, Jiangsu, Peoples R China
[2] Jilin Univ, Clin Med Coll, Changchun 130000, Jilin, Peoples R China
[3] Jilin Univ, Clin Med Coll, Changchun, Jilin, Peoples R China
来源：
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2017年 / 63卷 / 12期
关键词：
granulocyte-macrophage colony-stimulating factor; drug therapy; febrile neutropenia; FEBRILE NEUTROPENIA; ANTITUMOR IMMUNITY; VERSION; 3.2013; GROWTH-FACTORS; MORTALITY; CELLS;
D O I：
10.1590/1806-9282.63.12.1061
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: The present study was designed to evaluate safety and efficacy of recombinant human granulocyte colony stimulating factor (G-CSF) injection and whether this regimen could reduce the incidence of adverse events caused by chemotherapy. Method: A total of 100 patients with colon cancer who were treated with chemotherapy in our hospital from January 2011 to December 2014 were randomly divided into two groups, with 50 patients in each group. The patients in the treatment group received G-CSF 24 hours after chemotherapy for consecutive three days; the patients in the control group received the same dose of normal saline. Routine blood tests were performed 7 days and 14 days after chemotherapy. Results: Compared with the control group, the incidences of febrile neutropenia and leukocytopenia in the treatment group were significantly lower (p<0.05). In addition, the incidence of liver dysfunction in the treatment group was lower than that of the control group, without statistical significance. The incidence of myalgia in the treatment was higher than that of the control group without statistical significance. Conclusion: The present study indicated that G-CSF injection after chemotherapy is safe and effective for preventing adverse events in colon cancer patients with chemotherapy.
引用
收藏
页码：1061 / 1064
页数：4
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