Insufficiency Fracture Associated With Oncogenic Osteomalacia

被引:4
作者
Niemeier, Thomas [1 ]
Leddy, Lee [1 ]
Bolster, Marcy [1 ]
Chapin, Russell [1 ]
机构
[1] Med Univ S Carolina, Charleston, SC 29425 USA
关键词
oncogenic osteomalacia; tumor-induced osteomalacia; paraneoplastic; octreotide; MESENCHYMAL TUMORS;
D O I
10.1097/RHU.0b013e31827cd112
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Oncogenic osteomalacia is a rare paraneoplastic syndrome of systemic bone demineralization secondary to a tumor-induced dysregulation of phosphorus metabolism. The tumor's low prevalence, small size, and variable location often result in years of muscular weakness and bone pain before diagnosis. With complete treatment, patient's symptoms swiftly dissipate. We report the case of a 63-year-old previously healthy man with a 20-month course of musculoskeletal symptoms before diagnosis and resection of a posterior tibial tumor. Postoperatively, the patient had returned to his previous lifestyle when an insufficiency fracture required prophylactic stabilization.
引用
收藏
页码:38 / 42
页数:5
相关论文
共 21 条
[1]   Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets [J].
Alon, Uri S. ;
Levy-Olomucki, Rachel ;
Moore, Wayne V. ;
Stubbs, Jason ;
Liu, Shiguang ;
Quarles, L. Darryl .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 3 (03) :658-664
[2]   Anti-FGF-23 Neutralizing Antibodies Ameliorate Muscle Weakness and Decreased Spontaneous Movement of Hyp Mice [J].
Aono, Yukiko ;
Hasegawa, Hisashi ;
Yamazaki, Yuji ;
Shimada, Takashi ;
Fujita, Toshiro ;
Yamashita, Takeyoshi ;
Fukumoto, Seiji .
JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (04) :803-810
[3]   Tumor-induced osteomalacia [J].
Chong, William H. ;
Molinolo, Alfredo A. ;
Chen, Clara C. ;
Collins, Michael T. .
ENDOCRINE-RELATED CANCER, 2011, 18 (03) :R53-R77
[4]  
Chua SC, 2008, BRIT J RADIOL, V81, P110
[5]   Localisation of mesenchymal tumours by somatostatin receptor imaging [J].
de Beur, SMJ ;
Streeten, EA ;
Civelek, AC ;
McCarthy, EF ;
Uribe, L ;
Marx, SJ ;
Onobrakpeya, O ;
Raisz, LG ;
Watts, NB ;
Sharon, M ;
Levine, MA .
LANCET, 2002, 359 (9308) :761-763
[6]   Tumor-Induced Osteomalacia [J].
Drezner M.K. .
Reviews in Endocrine and Metabolic Disorders, 2001, 2 (2) :175-186
[7]  
Dupond Jean-Louis, 2005, Eur J Intern Med, V16, P445, DOI 10.1016/j.ejim.2005.07.003
[8]   Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity - An analysis of 32 cases and a comprehensive review of the literature [J].
Folpe, AL ;
Fanburg-Smith, JC ;
Billings, SD ;
Bisceglia, M ;
Bertoni, F ;
Cho, JY ;
Econs, MJ ;
Inwards, CY ;
de Beur, SMJ ;
Mentzel, T ;
Montgomery, E ;
Michal, M ;
Miettinen, M ;
Mills, SE ;
Reith, JD ;
O'Connell, JX ;
Rosenberg, AE ;
Rubin, BP ;
Sweet, DE ;
Vinh, TN ;
Wold, LE ;
Wehrli, BM ;
White, FKE ;
Zaino, RJ ;
Weiss, SW .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2004, 28 (01) :1-30
[9]   Cinacalcet in the management of tumor-induced osteomalacia [J].
Geller, Jordan L. ;
Khosravi, Azarmindokht ;
Kelly, Marilyn H. ;
Riminucci, Mara ;
Adams, John S. ;
Collins, Michael T. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (06) :931-937
[10]   FGF-23 is elevated by chronic hyperphosphatemia [J].
Gupta, A ;
Winer, K ;
Econs, MJ ;
Marx, SJ ;
Collins, MT .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) :4489-4492