Tongue muscle plasticity following hypoglossal nerve stimulation in aged rats

被引:25
作者
Connor, Nadine P. [1 ,2 ]
Russell, John A. [1 ,2 ]
Jackson, Michelle A. [3 ]
Kletzien, Heidi [1 ]
Wang, Hao [1 ]
Schaser, Allison J. [1 ,2 ]
Leverson, Glen E. [1 ]
Zealear, David L. [4 ]
机构
[1] Univ Wisconsin, Dept Surg Otolaryngol Head & Neck Surg, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Commun Disorders, Madison, WI 53792 USA
[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[4] Vanderbilt Univ, Dept Otolaryngol Head & Neck Surg, Nashville, TN USA
关键词
aging; electrical stimulation; muscle contraction; swallowing; tongue; NEUROMUSCULAR ELECTRICAL-STIMULATION; HEAVY-CHAIN ISOFORMS; CONTRACTILE PROPERTIES; SKELETAL-MUSCLE; MOTOR UNITS; POSTERIOR GENIOGLOSSUS; FREQUENCY STIMULATION; RETRACTOR MUSCLES; STROKE PATIENTS; FIBER TYPES;
D O I
10.1002/mus.23499
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Age-related decreases in tongue muscle mass and strength have been reported. It may be possible to prevent age-related tongue muscle changes using neuromuscular electrical stimulation (NMES). Our hypothesis was that alterations in muscle contractile properties and myosin heavy chain composition would be found after NMES. Methods: Fifty-four young, middle-aged, and old 344/Brown Norway rats were included in this study. Twenty-four rats underwent bilateral electrical stimulation of the hypoglossal nerves for 8 weeks and were compared with control or sham rats. Muscle contractile properties and myosin heavy chain (MHC) in the genioglossus (GG), styloglossus (SG), and hyoglossus (HG) muscles were examined. Results: Compared with unstimulated control rats, we found reduced muscle fatigue, increased contraction and half-decay times, and increased twitch and tetanic tension. Increased type I MHC was found, except for in GG in old and middle-aged rats. Conclusion: Transitions in tongue muscle contractile properties and phenotype were found after NMES. Muscle Nerve 47: 230-240, 2013
引用
收藏
页码:230 / 240
页数:11
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