Tongue muscle plasticity following hypoglossal nerve stimulation in aged rats

被引：25

作者：

Connor, Nadine P. ^{[1
,2
]}

Russell, John A. ^{[1
,2
]}

Jackson, Michelle A. ^{[3
]}

Kletzien, Heidi ^{[1
]}

Wang, Hao ^{[1
]}

Schaser, Allison J. ^{[1
,2
]}

Leverson, Glen E. ^{[1
]}

Zealear, David L. ^{[4
]}

机构：

[1] Univ Wisconsin, Dept Surg Otolaryngol Head & Neck Surg, Madison, WI 53792 USA

[2] Univ Wisconsin, Dept Commun Disorders, Madison, WI 53792 USA

[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[4] Vanderbilt Univ, Dept Otolaryngol Head & Neck Surg, Nashville, TN USA

来源：

MUSCLE & NERVE | 2013年 / 47卷 / 02期

关键词：

aging; electrical stimulation; muscle contraction; swallowing; tongue; NEUROMUSCULAR ELECTRICAL-STIMULATION; HEAVY-CHAIN ISOFORMS; CONTRACTILE PROPERTIES; SKELETAL-MUSCLE; MOTOR UNITS; POSTERIOR GENIOGLOSSUS; FREQUENCY STIMULATION; RETRACTOR MUSCLES; STROKE PATIENTS; FIBER TYPES;

D O I：

10.1002/mus.23499

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Age-related decreases in tongue muscle mass and strength have been reported. It may be possible to prevent age-related tongue muscle changes using neuromuscular electrical stimulation (NMES). Our hypothesis was that alterations in muscle contractile properties and myosin heavy chain composition would be found after NMES. Methods: Fifty-four young, middle-aged, and old 344/Brown Norway rats were included in this study. Twenty-four rats underwent bilateral electrical stimulation of the hypoglossal nerves for 8 weeks and were compared with control or sham rats. Muscle contractile properties and myosin heavy chain (MHC) in the genioglossus (GG), styloglossus (SG), and hyoglossus (HG) muscles were examined. Results: Compared with unstimulated control rats, we found reduced muscle fatigue, increased contraction and half-decay times, and increased twitch and tetanic tension. Increased type I MHC was found, except for in GG in old and middle-aged rats. Conclusion: Transitions in tongue muscle contractile properties and phenotype were found after NMES. Muscle Nerve 47: 230-240, 2013

引用

页码：230 / 240

页数：11

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