Currently, Web 2.0 media are becoming more popular and in fact have formed a community wherein people can share their learning experiences with others. Many web 2.0 scientific teaching materials have the potential to increase reflection, sense of community and collaboration in the teaching, such as blogs, wilds and social networking sites. The purpose of this study was to construct a framework of double main body interactive teaching model based on web 2.0. The double main body interactive teaching model advocates teachers and students being the main body for each other in teaching activities, enabling both teachers and students to develop their initiative creativity actively and stimulate the other side to do so, so as to achieve mutual improvement. By employed a blog-based case, the model has been verified that it was an effective teaching model. The results show that both the teacher and students can get benefits from the double main body interactive teaching based on web 2.0.