Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study

被引：3

作者：

Grau-Perez, Maria ^{[1
,2
]}

Kuo, Chin-Chi ^{[1
,3
,4
,5
,6
,7
,8
]}

Gribble, Matthew O. ^{[9
]}

Balakrishnan, Poojitha ^{[1
,2
,3
]}

Spratlen, Miranda Jones ^{[1
,2
]}

Vaidya, Dhananjay ^{[10
]}

Francesconi, Kevin A. ^{[11
]}

Goessler, Walter ^{[11
]}

Guallar, Eliseo ^{[3
,4
,12
]}

Silbergeld, Ellen K. ^{[1
]}

Umans, Jason G. ^{[13
,14
]}

Best, Lyle G. ^{[15
]}

Lee, Elisa T. ^{[16
]}

Howard, Barbara, V ^{[13
,14
]}

Cole, Shelley A. ^{[17
]}

Navas-Acien, Ana ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth & Engn, Baltimore, MD USA

[2] Columbia Univ, Dept Environm Hlth Sci, Mailman Sch Publ Hlth, New York, NY 10032 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA

[5] China Med Univ Hosp, Kidney Inst, Taichung, Taiwan

[6] China Med Univ Hosp, Div Nephrol, Dept Internal Med, Taichung, Taiwan

[7] China Med Univ, China Med Univ Hosp, Big Data Ctr, Taichung, Taiwan

[8] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan

[9] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA

[10] Johns Hopkins Sch Med, Dept Med, Div Gen Internal Med, Baltimore, MD USA

[11] Karl Franzens Univ Graz, Inst Chem, Graz, Austria

[12] Johns Hopkins Sch Med, Dept Med, Baltimore, MD USA

[13] Georgetown Howard Univ Ctr Clin & Translat Sci, Washington, DC USA

[14] MedStar Hlth Res Inst, Hyattsville, MD USA

[15] Missouri Breaks Ind Res Inc, Dept Epidemiol, Eagle Butte, SD USA

[16] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Ctr Amer Indian Hlth Res, Oklahoma City, OK USA

[17] Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2017年 / 125卷 / 12期

基金：

美国国家卫生研究院;

关键词：

FOLIC-ACID-SUPPLEMENTATION; DRINKING-WATER; LOW-LEVEL; CARDIOVASCULAR-DISEASE; AMERICAN-INDIANS; RISK; PREVALENCE; HOMEOSTASIS; TOXICOLOGY;

D O I：

10.1289/EHP2566

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

BACKGROUND: High arsenic exposure has been related to diabetes, but at low-moderate levels the evidence is mixed. Arsenic metabolism, which is partly genetically controlled and may rely on certain B vitamins, plays a role in arsenic toxicity. OBJECTIVE: We evaluated the prospective association of arsenic exposure and metabolism with type 2 diabetes and insulin resistance. METHODS: We included 1,838 American Indian men and women free of diabetes (median age, 36 y). Arsenic exposure was assessed as the sum of inorganic arsenic (iAs), monomethylarsonate (MMA), and dimethylarsinate (DMA) urine concentrations (Sigma As). Arsenic metabolism was evaluated by the proportions of iAs, MMA, and DMA over their sum (iAs%, MMA%, and DMA%). Homeostasis model assessment for insulin resistance (HOMA2-IR) was measured at baseline and follow-up visits. Incident diabetes was evaluated at follow-up. RESULTS: Median EAs, iAs%, MMA%, and DMA% was 4.4 mu g/g creatinine, 9.5%, 14.4%, and 75.6%, respectively. Over 10,327 person-years of follow-up, 252 participants developed diabetes. :Median HOMA2-IR at baseline was 1.5. The fully adjusted hazard ratio [95% confidence interval (CI)] for incident diabetes per an interquardle range increase in Sigma As was 1.57 (95% CI: 1.18, 2.08) in participants without prediabetes at baseline. Arsenic metabolism was not associated with incident diabetes. Sigma As was positively associated with HOMA2-IR at baseline but negatively with HOMA2-IR at follow-up. Increased MMA% was associated with lower HOMA2-IR when either iAs% or DMA% decreased. The association of arsenic metabolism with HOMA2-IR differed by B-vitamin intake and AS3MT genetics variants. CONCLUSIONS: Among participants without baseline prediabetes, arsenic exposure was associated with incident diabetes. Low MMA% was cross-sectional and prospectively associated with higher HOMA2-IR. Research is needed to confirm possible interactions of arsenic metabolism with B vitamins and AS3MT variants on diabetes risk. https://doi.org/10.1289/EHP2566

引用

页数：9

共 45 条

[41] Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: Evidence from the Strong Heart Study
Spratlen, Miranda Jones
Gamble, Mary V.
Grau-Perez, Maria
Kuo, Chin-Chi
Best, Lyle G.
Yracheta, Joseph
Francesconi, Kevin
Goessler, Walter
Mossavar-Rahmani, Yasmin
Hall, Meghan
Umans, Jason G.
Fretts, Amanda
Navas-Acien, Ana
[J]. FOOD AND CHEMICAL TOXICOLOGY, 2017, 105 : 387 - 397
[42] Mechanisms of arsenic biotransformation
Vahter, M
[J]. TOXICOLOGY, 2002, 181 : 211 - 217
[43] Use and abuse of HOMA modeling
Wallace, TM
Levy, JC
Matthews, DR
[J]. DIABETES CARE, 2004, 27 (06) : 1487 - 1495
[44] CARDIOVASCULAR-DISEASE AMONG AMERICAN-INDIANS AND ALASKA NATIVES
WELTY, TK
COULEHAN, JL
[J]. DIABETES CARE, 1993, 16 (01) : 277 - 283
[45] Prevalence of chronic diseases in adults exposed to arsenic-contaminated drinking water
Zierold, KM
Knobeloch, L
Anderson, H
[J]. AMERICAN JOURNAL OF PUBLIC HEALTH, 2004, 94 (11) : 1936 - 1937

← 1 2 3 4 5 →